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- NCIT_C151947 IAO_0000115 "An immunoglobulin G1 (IgG1), human monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, cosibelimab specifically targets and binds to PD-L1, blocking its binding to and activation of its receptor programmed cell death protein 1 (PD-1; PDCD1; CD279; programmed death-1). This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in immune evasion. PD-1, a transmembrane protein belonging to the immunoglobulin superfamily expressed on activated T-cells, is a negative regulator of the immune system that limits the expansion and survival of CD8-positive T-cells." @default.
- NCIT_C151947 NCIT_A32 NCIT_C1909 @default.
- NCIT_C151947 NCIT_A7 NCIT_C96024 @default.
- NCIT_C151947 NCIT_NHC0 "C151947" @default.
- NCIT_C151947 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C151947 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C151947 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C151947 NCIT_P107 "Anti-PD-L1 Monoclonal Antibody TG-1501" @default.
- NCIT_C151947 NCIT_P108 "Cosibelimab" @default.
- NCIT_C151947 NCIT_P208 "CL937684" @default.
- NCIT_C151947 NCIT_P210 "2216751-26-5" @default.
- NCIT_C151947 NCIT_P319 "PNW7GBB44P" @default.
- NCIT_C151947 NCIT_P322 "CTRP" @default.
- NCIT_C151947 NCIT_P322 "FDA" @default.
- NCIT_C151947 NCIT_P322 "GDC" @default.
- NCIT_C151947 NCIT_P329 "793157" @default.
- NCIT_C151947 NCIT_P330 "793157" @default.
- NCIT_C151947 NCIT_P375 "Anti-PD-L1 Monoclonal Antibody CK-301" @default.
- NCIT_C151947 NCIT_P375 "Anti-PD-L1 Monoclonal Antibody TG-1501" @default.
- NCIT_C151947 NCIT_P375 "Cosibelimab" @default.
- NCIT_C151947 NCIT_P399 "793157" @default.
- NCIT_C151947 NCIT_R124 NCIT_C17710 @default.
- NCIT_C151947 NCIT_R124 NCIT_C17828 @default.
- NCIT_C151947 NCIT_R124 NCIT_C18219 @default.
- NCIT_C151947 NCIT_R124 NCIT_C19986 @default.
- NCIT_C151947 NCIT_R124 NCIT_C40474 @default.
- NCIT_C151947 normalizedInformationContent "100" @default.
- NCIT_C151947 referenceCount "1" @default.
- NCIT_C151947 hasExactSynonym "Anti-PD-L1 Monoclonal Antibody TG-1501" @default.
- NCIT_C151947 hasExactSynonym "Anti-PDL1 Monoclonal Antibody TG-1501" @default.
- NCIT_C151947 hasExactSynonym "CK 301" @default.
- NCIT_C151947 hasExactSynonym "CK-301" @default.
- NCIT_C151947 hasExactSynonym "COSIBELIMAB" @default.
- NCIT_C151947 hasExactSynonym "Cosibelimab" @default.
- NCIT_C151947 hasExactSynonym "TG 1501" @default.
- NCIT_C151947 hasExactSynonym "TG-1501" @default.
- NCIT_C151947 hasExactSynonym "TG1501" @default.
- NCIT_C151947 inSubset NCIT_C116977 @default.
- NCIT_C151947 inSubset NCIT_C116978 @default.
- NCIT_C151947 inSubset NCIT_C128784 @default.
- NCIT_C151947 inSubset NCIT_C157711 @default.
- NCIT_C151947 inSubset NCIT_C157712 @default.
- NCIT_C151947 inSubset NCIT_C176424 @default.
- NCIT_C151947 inSubset NCIT_C177537 @default.
- NCIT_C151947 inSubset NCIT_C63923 @default.
- NCIT_C151947 type Class @default.
- NCIT_C151947 isDefinedBy ncit.owl @default.
- NCIT_C151947 label "Cosibelimab" @default.
- NCIT_C151947 subClassOf NCIT_C128057 @default.
- NCIT_C151947 subClassOf NCIT_C129821 @default.
- NCIT_C151947 subClassOf NCIT_C129822 @default.
- NCIT_C151947 subClassOf NCIT_C141144 @default.
- NCIT_C151947 subClassOf NCIT_C143250 @default.
- NCIT_C151947 subClassOf NCIT_C151947 @default.
- NCIT_C151947 subClassOf NCIT_C156893 @default.
- NCIT_C151947 subClassOf NCIT_C163758 @default.
- NCIT_C151947 subClassOf NCIT_C1908 @default.
- NCIT_C151947 subClassOf NCIT_C1909 @default.
- NCIT_C151947 subClassOf NCIT_C191689 @default.
- NCIT_C151947 subClassOf NCIT_C20401 @default.
- NCIT_C151947 subClassOf NCIT_C274 @default.
- NCIT_C151947 subClassOf NCIT_C307 @default.
- NCIT_C151947 subClassOf NCIT_C308 @default.