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- NCIT_C151949 IAO_0000115 "The fumarate salt form of vonoprazan, a pyrrole derivative and reversible potassium-competitive acid blocker (P-CAB), with potential antacid activity. Upon administration, vonoprazan specifically and competitively binds to the gastric hydrogen-potassium ATPase (H+/K+ ATPase) proton pump at or, more likely, near its potassium ion (K+) binding site and sterically inhibits K+ binding. This blocks the activation of the H+/K+ ATPase by K+, inhibits the proton pump and prevents gastric acid secretion, thereby lowering gastric acid levels." @default.
- NCIT_C151949 NCIT_NHC0 "C151949" @default.
- NCIT_C151949 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C151949 NCIT_P108 "Vonoprazan Fumarate" @default.
- NCIT_C151949 NCIT_P208 "CL553177" @default.
- NCIT_C151949 NCIT_P210 "881681-01-2" @default.
- NCIT_C151949 NCIT_P319 "4QW3X4AMLB" @default.
- NCIT_C151949 NCIT_P322 "FDA" @default.
- NCIT_C151949 NCIT_P329 "793169" @default.
- NCIT_C151949 NCIT_P330 "793169" @default.
- NCIT_C151949 NCIT_P399 "793169" @default.
- NCIT_C151949 normalizedInformationContent "100" @default.
- NCIT_C151949 referenceCount "1" @default.
- NCIT_C151949 hasExactSynonym "1H-Pyrrole-3-methanamine, 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-, (2E)-2-Butenedioate (1:1)" @default.
- NCIT_C151949 hasExactSynonym "TAK-438" @default.
- NCIT_C151949 hasExactSynonym "Takecab" @default.
- NCIT_C151949 hasExactSynonym "VONOPRAZAN FUMARATE" @default.
- NCIT_C151949 hasExactSynonym "Vonoprazan Fumarate" @default.
- NCIT_C151949 inSubset NCIT_C176424 @default.
- NCIT_C151949 inSubset NCIT_C63923 @default.
- NCIT_C151949 type Class @default.
- NCIT_C151949 isDefinedBy ncit.owl @default.
- NCIT_C151949 label "Vonoprazan Fumarate" @default.
- NCIT_C151949 subClassOf NCIT_C151949 @default.
- NCIT_C151949 subClassOf NCIT_C1908 @default.
- NCIT_C151949 subClassOf NCIT_C1909 @default.
- NCIT_C151949 subClassOf NCIT_C2080 @default.
- NCIT_C151949 subClassOf NCIT_C2459 @default.
- NCIT_C151949 subClassOf NCIT_C26170 @default.
- NCIT_C151949 subClassOf NCIT_C29701 @default.
- NCIT_C151949 subClassOf NCIT_C78276 @default.