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- NCIT_C151954 IAO_0000115 "A preparation of genetically modified autologous T-cells transduced with lentiviral vectors expressing chimeric antigen receptors (CARs) specific for the tumor-associated antigens (TAAs) mucin 1 (Muc1; MUC1), cluster of differentiation 33 (CD33), CD38, CD56 and CD123 (interleukin-3 receptor alpha chain or IL3RA), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-Muc1/CD33/CD38/CD56/CD123 gene-engineered CAR-T cells are directed to and induce selective toxicity in Muc1/CD33/CD38/CD56/CD123-expressing tumor cells. Muc1/CD33/CD38/CD56/CD123 are present on certain tumor cell types and are minimally expressed on normal, healthy cells. Expression of these TAAs are correlated with poor prognosis. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules included in the CARs, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity." @default.
- NCIT_C151954 NCIT_NHC0 "C151954" @default.
- NCIT_C151954 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C151954 NCIT_P108 "Autologous Anti-Muc1/CD33/CD38/CD56/CD123 Gene-engineered CAR-T Cells" @default.
- NCIT_C151954 NCIT_P208 "CL553182" @default.
- NCIT_C151954 NCIT_P329 "793184" @default.
- NCIT_C151954 NCIT_P330 "793184" @default.
- NCIT_C151954 NCIT_P399 "793184" @default.
- NCIT_C151954 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C151954 NCIT_R125 NCIT_C18839 @default.
- NCIT_C151954 NCIT_R125 NCIT_C19053 @default.
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- NCIT_C151954 NCIT_R72 NCIT_C104083 @default.
- NCIT_C151954 NCIT_R72 NCIT_C12219 @default.
- NCIT_C151954 NCIT_R72 NCIT_C12476 @default.
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- NCIT_C151954 NCIT_R72 NCIT_C12535 @default.
- NCIT_C151954 NCIT_R72 NCIT_C12542 @default.
- NCIT_C151954 NCIT_R72 NCIT_C12543 @default.
- NCIT_C151954 NCIT_R72 NCIT_C21599 @default.
- NCIT_C151954 NCIT_R72 NCIT_C32725 @default.
- NCIT_C151954 NCIT_R72 NCIT_C33061 @default.
- NCIT_C151954 NCIT_R72 NCIT_C38434 @default.
- NCIT_C151954 NCIT_R72 NCIT_C38439 @default.
- NCIT_C151954 NCIT_R72 NCIT_C39567 @default.
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- NCIT_C151954 normalizedInformationContent "100" @default.
- NCIT_C151954 referenceCount "1" @default.
- NCIT_C151954 hasExactSynonym "Autologous Anti-Muc1/CD33/CD38/CD56/CD123 Gene-engineered CAR-T Cells" @default.
- NCIT_C151954 hasExactSynonym "Autologous Muc1/CD33/CD38/CD56/CD123-specific Gene-engineered CAR-T Cells" @default.
- NCIT_C151954 inSubset NCIT_C128784 @default.
- NCIT_C151954 inSubset NCIT_C176424 @default.
- NCIT_C151954 type Class @default.
- NCIT_C151954 isDefinedBy ncit.owl @default.
- NCIT_C151954 label "Autologous Anti-Muc1/CD33/CD38/CD56/CD123 Gene-engineered CAR-T Cells" @default.
- NCIT_C151954 subClassOf NCIT_C129820 @default.
- NCIT_C151954 subClassOf NCIT_C129821 @default.
- NCIT_C151954 subClassOf NCIT_C129826 @default.
- NCIT_C151954 subClassOf NCIT_C137999 @default.
- NCIT_C151954 subClassOf NCIT_C142078 @default.
- NCIT_C151954 subClassOf NCIT_C151954 @default.
- NCIT_C151954 subClassOf NCIT_C154231 @default.
- NCIT_C151954 subClassOf NCIT_C1908 @default.
- NCIT_C151954 subClassOf NCIT_C1909 @default.
- NCIT_C151954 subClassOf NCIT_C1962 @default.
- NCIT_C151954 subClassOf NCIT_C200766 @default.
- NCIT_C151954 subClassOf NCIT_C201493 @default.
- NCIT_C151954 subClassOf NCIT_C201495 @default.
- NCIT_C151954 subClassOf NCIT_C274 @default.
- NCIT_C151954 subClassOf NCIT_C28681 @default.
- NCIT_C151954 subClassOf NCIT_C307 @default.
- NCIT_C151954 subClassOf NCIT_C308 @default.