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- NCIT_C151955 IAO_0000115 "The sodium hydrate form of upacicalcet, an agonist of calcium-sensing receptors (CaSR), with potential use in the treatment of secondary hyperparathyroidism (SHPT). Upon administration, upacicalcet targets and binds to CaSRs expressed on the membranes of cells in the parathyroid glands, which suppresses osteoclast activity and reduces the excessive secretion of parathyroid hormone (PTH). This prevents the excessive PTH-mediated efflux of phosphorus and calcium from bone into the blood and normalizes serum calcium and phosphorus levels. Upacicalcet may decrease the risk of bone fracture, may lower depositions of phosphorus and calcium salts in non-bone tissues, may reduce bone and joint pain and may slow the progression of other diseases related to increased levels of PTH. CaSR controls calcium homeostasis and regulates the release of PTH." @default.
- NCIT_C151955 NCIT_A6 NCIT_C166837 @default.
- NCIT_C151955 NCIT_NHC0 "C151955" @default.
- NCIT_C151955 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C151955 NCIT_P108 "Upacicalcet Sodium Hydrate" @default.
- NCIT_C151955 NCIT_P208 "CL553183" @default.
- NCIT_C151955 NCIT_P319 "DH9LW5L96P" @default.
- NCIT_C151955 NCIT_P322 "FDA" @default.
- NCIT_C151955 NCIT_P329 "793192" @default.
- NCIT_C151955 NCIT_P330 "793192" @default.
- NCIT_C151955 NCIT_P399 "793192" @default.
- NCIT_C151955 normalizedInformationContent "100" @default.
- NCIT_C151955 referenceCount "1" @default.
- NCIT_C151955 hasExactSynonym "AJT-240" @default.
- NCIT_C151955 hasExactSynonym "AJT240" @default.
- NCIT_C151955 hasExactSynonym "CaSR Agonist SK 1403" @default.
- NCIT_C151955 hasExactSynonym "Calcium-sensing Receptor Agonist SK 1403" @default.
- NCIT_C151955 hasExactSynonym "PLS 240" @default.
- NCIT_C151955 hasExactSynonym "PLS-240" @default.
- NCIT_C151955 hasExactSynonym "PLS240" @default.
- NCIT_C151955 hasExactSynonym "SK1403" @default.
- NCIT_C151955 hasExactSynonym "UPACICALCET SODIUM HYDRATE" @default.
- NCIT_C151955 hasExactSynonym "UPASITA" @default.
- NCIT_C151955 hasExactSynonym "Upacicalcet Sodium Hydrate" @default.
- NCIT_C151955 inSubset NCIT_C176424 @default.
- NCIT_C151955 inSubset NCIT_C63923 @default.
- NCIT_C151955 type Class @default.
- NCIT_C151955 isDefinedBy ncit.owl @default.
- NCIT_C151955 label "Upacicalcet Sodium Hydrate" @default.
- NCIT_C151955 subClassOf NCIT_C151955 @default.
- NCIT_C151955 subClassOf NCIT_C1908 @default.
- NCIT_C151955 subClassOf NCIT_C1909 @default.
- NCIT_C151955 subClassOf NCIT_C78281 @default.