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- NCIT_C151994 IAO_0000115 "An orally administered prodrug of napabucasin, a small molecule cancer stemness inhibitor with potential antineoplastic activity. Upon administration, DSP-0337 is converted to its active form, napabucasin. Napabucasin targets and inhibits signal transducer and activator of transcription 3 (STAT3), thereby preventing STAT-3-mediated signaling. The STAT3 pathway is overly active in many cancer types and is implicated in cancer stem cell-mediated growth, recurrence and resistance to conventional chemotherapies." @default.
- NCIT_C151994 NCIT_A32 NCIT_C1909 @default.
- NCIT_C151994 NCIT_A7 NCIT_C28664 @default.
- NCIT_C151994 NCIT_NHC0 "C151994" @default.
- NCIT_C151994 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C151994 NCIT_P107 "STAT3 Inhibitor DSP-0337" @default.
- NCIT_C151994 NCIT_P108 "STAT3 Inhibitor DSP-0337" @default.
- NCIT_C151994 NCIT_P208 "CL553215" @default.
- NCIT_C151994 NCIT_P322 "CTRP" @default.
- NCIT_C151994 NCIT_P322 "GDC" @default.
- NCIT_C151994 NCIT_P329 "793774" @default.
- NCIT_C151994 NCIT_P330 "793774" @default.
- NCIT_C151994 NCIT_P375 "STAT3 Inhibitor DSP-0337" @default.
- NCIT_C151994 NCIT_P399 "793774" @default.
- NCIT_C151994 normalizedInformationContent "100" @default.
- NCIT_C151994 referenceCount "1" @default.
- NCIT_C151994 hasExactSynonym "Cancer Stemness Inhibitor DSP-0337" @default.
- NCIT_C151994 hasExactSynonym "DSP 0337" @default.
- NCIT_C151994 hasExactSynonym "DSP-0337" @default.
- NCIT_C151994 hasExactSynonym "Napabucasin Prodrug DSP-0337" @default.
- NCIT_C151994 hasExactSynonym "STAT3 Inhibitor DSP-0337" @default.
- NCIT_C151994 inSubset NCIT_C116977 @default.
- NCIT_C151994 inSubset NCIT_C116978 @default.
- NCIT_C151994 inSubset NCIT_C128784 @default.
- NCIT_C151994 inSubset NCIT_C157711 @default.
- NCIT_C151994 inSubset NCIT_C157712 @default.
- NCIT_C151994 inSubset NCIT_C176424 @default.
- NCIT_C151994 inSubset NCIT_C177537 @default.
- NCIT_C151994 type Class @default.
- NCIT_C151994 isDefinedBy ncit.owl @default.
- NCIT_C151994 label "STAT3 Inhibitor DSP-0337" @default.
- NCIT_C151994 subClassOf NCIT_C151994 @default.
- NCIT_C151994 subClassOf NCIT_C1908 @default.
- NCIT_C151994 subClassOf NCIT_C1909 @default.
- NCIT_C151994 subClassOf NCIT_C2189 @default.
- NCIT_C151994 subClassOf NCIT_C274 @default.