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- NCIT_C152135 IAO_0000115 "The succinate form of rabacfosadine, an acyclic nucleotide phosphonate prodrug and polymerase inhibitor that can potentially be used for its antineoplastic activity in the treatment of lymphoma in dogs. Upon administration, rabacfosadine is hydrolyzed intracellularly to 9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2, 6-diaminopurine (cPrPMEDAP) and subsequently deaminated to 9-(2-phosphonylmethoxyethyl) guanine (PMEG) and phosphorylated to PMEG diphosphate (PMEGpp). PMEGpp binds to and inhibits DNA polymerases. This inhibits DNA synthesis, resulting in S phase arrest and induction of apoptosis." @default.
- NCIT_C152135 NCIT_NHC0 "C152135" @default.
- NCIT_C152135 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152135 NCIT_P108 "Rabacfosadine Succinate" @default.
- NCIT_C152135 NCIT_P208 "CL553467" @default.
- NCIT_C152135 NCIT_P210 "1431856-99-3" @default.
- NCIT_C152135 NCIT_P319 "3L28LG748I" @default.
- NCIT_C152135 NCIT_P322 "FDA" @default.
- NCIT_C152135 normalizedInformationContent "100" @default.
- NCIT_C152135 referenceCount "1" @default.
- NCIT_C152135 hasExactSynonym "RABACFOSADINE SUCCINATE" @default.
- NCIT_C152135 hasExactSynonym "Rabacfosadine Succinate" @default.
- NCIT_C152135 inSubset NCIT_C63923 @default.
- NCIT_C152135 type Class @default.
- NCIT_C152135 isDefinedBy ncit.owl @default.
- NCIT_C152135 label "Rabacfosadine Succinate" @default.
- NCIT_C152135 subClassOf NCIT_C129824 @default.
- NCIT_C152135 subClassOf NCIT_C129825 @default.
- NCIT_C152135 subClassOf NCIT_C152135 @default.
- NCIT_C152135 subClassOf NCIT_C1908 @default.
- NCIT_C152135 subClassOf NCIT_C1909 @default.
- NCIT_C152135 subClassOf NCIT_C2189 @default.
- NCIT_C152135 subClassOf NCIT_C274 @default.
- NCIT_C152135 subClassOf NCIT_C29575 @default.
- NCIT_C152135 subClassOf NCIT_C471 @default.