Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C152162> ?p ?o ?g. }
Showing items 1 to 35 of
35
with 100 items per page.
- NCIT_C152162 IAO_0000115 "An orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Upon oral administration, rebastinib binds to and inhibits the Bcr-Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand-dependent and ligand-independent activation; in addition, this agent binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine kinases TIE-2 and VEGFR-2. Rebastinib may exhibit more potent activity against T315I Bcr-Abl gatekeeper mutant kinases than other Bcr-Abl kinase inhibitors. The TIE-2 and VEGFR-2 receptor tyrosine kinases regulate angiogenesis, respectively, while the Src family kinases Abl, LYN, and HCK Src regulate a variety of cellular responses including differentiation, division, adhesion, and the stress response." @default.
- NCIT_C152162 NCIT_A7 NCIT_C16325 @default.
- NCIT_C152162 NCIT_A7 NCIT_C17326 @default.
- NCIT_C152162 NCIT_A7 NCIT_C17483 @default.
- NCIT_C152162 NCIT_A7 NCIT_C18488 @default.
- NCIT_C152162 NCIT_A7 NCIT_C18558 @default.
- NCIT_C152162 NCIT_A7 NCIT_C28496 @default.
- NCIT_C152162 NCIT_NHC0 "C152162" @default.
- NCIT_C152162 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152162 NCIT_P107 "Rebastinib" @default.
- NCIT_C152162 NCIT_P108 "Rebastinib" @default.
- NCIT_C152162 NCIT_P208 "CL553494" @default.
- NCIT_C152162 NCIT_P210 "1020172-07-9" @default.
- NCIT_C152162 NCIT_P319 "75017Q6I97" @default.
- NCIT_C152162 NCIT_P322 "CTRP" @default.
- NCIT_C152162 NCIT_P322 "FDA" @default.
- NCIT_C152162 normalizedInformationContent "100" @default.
- NCIT_C152162 referenceCount "1" @default.
- NCIT_C152162 hasExactSynonym "DCC-2036" @default.
- NCIT_C152162 hasExactSynonym "REBASTINIB" @default.
- NCIT_C152162 hasExactSynonym "Rebastinib" @default.
- NCIT_C152162 inSubset NCIT_C116977 @default.
- NCIT_C152162 inSubset NCIT_C116978 @default.
- NCIT_C152162 inSubset NCIT_C63923 @default.
- NCIT_C152162 type Class @default.
- NCIT_C152162 isDefinedBy ncit.owl @default.
- NCIT_C152162 label "Rebastinib" @default.
- NCIT_C152162 subClassOf NCIT_C129824 @default.
- NCIT_C152162 subClassOf NCIT_C129825 @default.
- NCIT_C152162 subClassOf NCIT_C152162 @default.
- NCIT_C152162 subClassOf NCIT_C1908 @default.
- NCIT_C152162 subClassOf NCIT_C1909 @default.
- NCIT_C152162 subClassOf NCIT_C2189 @default.
- NCIT_C152162 subClassOf NCIT_C274 @default.
- NCIT_C152162 subClassOf NCIT_C471 @default.