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- NCIT_C152246 IAO_0000115 "A recombinant humanized immunoglobulin G2 (IgG2) monoclonal antibody directed against sclerostin, with anti-osteoporotic activity. Upon administration, romosozumab targets, binds to and inhibits the activity of sclerostin, a regulatory factor in bone metabolism. This stimulates osteoblastic activity, increases bone formation and, to a lesser extent, decreases bone resorption This may increase trabecular and cortical bone mass and improve bone structure and strength. Altogether, this may decrease the risk of fractures. Sclerostin, a negative regulator of bone formation secreted by osteocytes, inhibits Wnt signaling and suppresses osteoblast development and function." @default.
- NCIT_C152246 NCIT_NHC0 "C152246" @default.
- NCIT_C152246 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C152246 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152246 NCIT_P108 "Romosozumab" @default.
- NCIT_C152246 NCIT_P207 "C3661283" @default.
- NCIT_C152246 NCIT_P210 "909395-70-6" @default.
- NCIT_C152246 NCIT_P319 "3VHF2ZD92J" @default.
- NCIT_C152246 NCIT_P322 "FDA" @default.
- NCIT_C152246 NCIT_P399 "812844" @default.
- NCIT_C152246 NCIT_R124 NCIT_C17710 @default.
- NCIT_C152246 NCIT_R124 NCIT_C17828 @default.
- NCIT_C152246 NCIT_R124 NCIT_C18219 @default.
- NCIT_C152246 NCIT_R124 NCIT_C19986 @default.
- NCIT_C152246 NCIT_R124 NCIT_C40474 @default.
- NCIT_C152246 normalizedInformationContent "100" @default.
- NCIT_C152246 referenceCount "1" @default.
- NCIT_C152246 hasExactSynonym "Evenity" @default.
- NCIT_C152246 hasExactSynonym "ROMOSOZUMAB" @default.
- NCIT_C152246 hasExactSynonym "Romosozumab" @default.
- NCIT_C152246 hasExactSynonym "Romosozumab-aqqg" @default.
- NCIT_C152246 inSubset NCIT_C176424 @default.
- NCIT_C152246 inSubset NCIT_C63923 @default.
- NCIT_C152246 type Class @default.
- NCIT_C152246 isDefinedBy ncit.owl @default.
- NCIT_C152246 label "Romosozumab" @default.
- NCIT_C152246 subClassOf NCIT_C152246 @default.
- NCIT_C152246 subClassOf NCIT_C1908 @default.
- NCIT_C152246 subClassOf NCIT_C1909 @default.
- NCIT_C152246 subClassOf NCIT_C20401 @default.
- NCIT_C152246 subClassOf NCIT_C307 @default.
- NCIT_C152246 subClassOf NCIT_C308 @default.
- NCIT_C152246 subClassOf NCIT_C78281 @default.