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- NCIT_C152281 IAO_0000115 "A neprilysn (NEP) inhibitor prodrug with natriuretic activity. Upon administration, sacubitril is metabolized by esterases to its active metabolite, sacubitrilat, which inhibits NEP, a neutral endopeptidase that cleaves natriuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP), as well as certain vasoconstricting peptides including as angiotensin I and II, and endothelin-1. Additionally, sacubitrilat may inhibit NEP-mediated catabolism of certain peptide-based agents, thereby improving their in vivo stability and increasing tumor cell exposure." @default.
- NCIT_C152281 NCIT_NHC0 "C152281" @default.
- NCIT_C152281 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152281 NCIT_P108 "Sacubitril" @default.
- NCIT_C152281 NCIT_P208 "CL553613" @default.
- NCIT_C152281 NCIT_P210 "149709-62-6" @default.
- NCIT_C152281 NCIT_P319 "17ERJ0MKGI" @default.
- NCIT_C152281 NCIT_P322 "FDA" @default.
- NCIT_C152281 NCIT_P329 "798813" @default.
- NCIT_C152281 NCIT_P330 "798813" @default.
- NCIT_C152281 NCIT_P399 "798813" @default.
- NCIT_C152281 normalizedInformationContent "100" @default.
- NCIT_C152281 referenceCount "1" @default.
- NCIT_C152281 hasExactSynonym "(2R,4S)-5-(biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid ethyl ester" @default.
- NCIT_C152281 hasExactSynonym "AHU 377" @default.
- NCIT_C152281 hasExactSynonym "AHU-377" @default.
- NCIT_C152281 hasExactSynonym "AHU377" @default.
- NCIT_C152281 hasExactSynonym "SACUBITRIL" @default.
- NCIT_C152281 hasExactSynonym "Sacubitril" @default.
- NCIT_C152281 inSubset NCIT_C176424 @default.
- NCIT_C152281 inSubset NCIT_C63923 @default.
- NCIT_C152281 type Class @default.
- NCIT_C152281 isDefinedBy ncit.owl @default.
- NCIT_C152281 label "Sacubitril" @default.
- NCIT_C152281 subClassOf NCIT_C152281 @default.
- NCIT_C152281 subClassOf NCIT_C1908 @default.
- NCIT_C152281 subClassOf NCIT_C1909 @default.
- NCIT_C152281 subClassOf NCIT_C270 @default.
- NCIT_C152281 subClassOf NCIT_C78274 @default.