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- NCIT_C152302 IAO_0000115 "A recombinant, human immunoglobulin (IgG) monoclonal antibody targeting the interleukin 6 receptor (IL-6R), with potential anti-inflammatory activity. Upon intravenous administration of sarilumab, this agent targets and binds to both soluble IL-6 receptor (sIL-6R) and membrane-bound IL-6 receptor (mIL-6R). This inhibits the binding of the pro-inflammatory cytokine IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of the IL-6/IL-6R-mediated signal transduction pathway. This may inhibit IL-6/IL-6R-mediated inflammation." @default.
- NCIT_C152302 NCIT_A48 NCIT_C17998 @default.
- NCIT_C152302 NCIT_A48 NCIT_C49487 @default.
- NCIT_C152302 NCIT_A48 NCIT_C49488 @default.
- NCIT_C152302 NCIT_A7 NCIT_C156002 @default.
- NCIT_C152302 NCIT_A7 NCIT_C38921 @default.
- NCIT_C152302 NCIT_NHC0 "C152302" @default.
- NCIT_C152302 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C152302 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152302 NCIT_P107 "Sarilumab" @default.
- NCIT_C152302 NCIT_P108 "Sarilumab" @default.
- NCIT_C152302 NCIT_P207 "C3885145" @default.
- NCIT_C152302 NCIT_P210 "1189541-98-7" @default.
- NCIT_C152302 NCIT_P319 "NU90V55F8I" @default.
- NCIT_C152302 NCIT_P322 "ACC/AHA" @default.
- NCIT_C152302 NCIT_P322 "CTRP" @default.
- NCIT_C152302 NCIT_P322 "FDA" @default.
- NCIT_C152302 NCIT_P329 "803539" @default.
- NCIT_C152302 NCIT_P330 "803539" @default.
- NCIT_C152302 NCIT_P399 "803539" @default.
- NCIT_C152302 NCIT_R124 NCIT_C17710 @default.
- NCIT_C152302 NCIT_R124 NCIT_C17828 @default.
- NCIT_C152302 NCIT_R124 NCIT_C18219 @default.
- NCIT_C152302 NCIT_R124 NCIT_C19986 @default.
- NCIT_C152302 NCIT_R124 NCIT_C40474 @default.
- NCIT_C152302 normalizedInformationContent "100" @default.
- NCIT_C152302 referenceCount "1" @default.
- NCIT_C152302 hasExactSynonym "IL-6 receptor monoclonal antibodies: sarilumab" @default.
- NCIT_C152302 hasExactSynonym "Immunoglobulin G1, Anti-Human Interleukin 6 Receptor alpha) (Human REGN88 Heavy Chain), Disulfide with Human REGN88 Light Chain, Dimer" @default.
- NCIT_C152302 hasExactSynonym "Kevzara" @default.
- NCIT_C152302 hasExactSynonym "REGN88" @default.
- NCIT_C152302 hasExactSynonym "SAR153191" @default.
- NCIT_C152302 hasExactSynonym "SARILUMAB" @default.
- NCIT_C152302 hasExactSynonym "Sarilumab" @default.
- NCIT_C152302 inSubset NCIT_C116977 @default.
- NCIT_C152302 inSubset NCIT_C116978 @default.
- NCIT_C152302 inSubset NCIT_C173381 @default.
- NCIT_C152302 inSubset NCIT_C173383 @default.
- NCIT_C152302 inSubset NCIT_C176424 @default.
- NCIT_C152302 inSubset NCIT_C191200 @default.
- NCIT_C152302 inSubset NCIT_C191387 @default.
- NCIT_C152302 inSubset NCIT_C191404 @default.
- NCIT_C152302 inSubset NCIT_C191670 @default.
- NCIT_C152302 inSubset NCIT_C63923 @default.
- NCIT_C152302 type Class @default.
- NCIT_C152302 isDefinedBy ncit.owl @default.
- NCIT_C152302 label "Sarilumab" @default.
- NCIT_C152302 subClassOf NCIT_C152302 @default.
- NCIT_C152302 subClassOf NCIT_C1908 @default.
- NCIT_C152302 subClassOf NCIT_C190830 @default.
- NCIT_C152302 subClassOf NCIT_C1909 @default.
- NCIT_C152302 subClassOf NCIT_C20401 @default.
- NCIT_C152302 subClassOf NCIT_C307 @default.
- NCIT_C152302 subClassOf NCIT_C308 @default.
- NCIT_C152302 subClassOf NCIT_C574 @default.