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- NCIT_C152315 IAO_0000115 "A recombinant human immunoglobulin G1 (IgG1) monoclonal antibody against the pro-inflammatory cytokine interleukin 17A (IL-17A; IL-17), with potential anti-inflammatory activity. Upon subcutaneous administration, secukinumab selectively targets and binds to IL-17A, thereby neutralizing the IL-17A protein. This prevents binding of IL-17A to the IL-17 receptor (IL-17R), and inhibits IL-17A/IL-17R-mediated signaling and inflammation mediated by this pathway. IL-17A is mainly produced by inflammatory T helper 17 cells (Th17), and certain lymphocytes. IL-17A production is upregulated in many immune-mediated inflammatory diseases and plays a key role in the development of inflammation and the immune response." @default.
- NCIT_C152315 NCIT_NHC0 "C152315" @default.
- NCIT_C152315 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C152315 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152315 NCIT_P108 "Secukinumab" @default.
- NCIT_C152315 NCIT_P208 "CL553647" @default.
- NCIT_C152315 NCIT_P210 "1229022-83-6" @default.
- NCIT_C152315 NCIT_P319 "DLG4EML025" @default.
- NCIT_C152315 NCIT_P322 "FDA" @default.
- NCIT_C152315 NCIT_P329 "803239" @default.
- NCIT_C152315 NCIT_P330 "803239" @default.
- NCIT_C152315 NCIT_P399 "803239" @default.
- NCIT_C152315 NCIT_R124 NCIT_C17710 @default.
- NCIT_C152315 NCIT_R124 NCIT_C17828 @default.
- NCIT_C152315 NCIT_R124 NCIT_C18219 @default.
- NCIT_C152315 NCIT_R124 NCIT_C19986 @default.
- NCIT_C152315 NCIT_R124 NCIT_C40474 @default.
- NCIT_C152315 normalizedInformationContent "100" @default.
- NCIT_C152315 referenceCount "1" @default.
- NCIT_C152315 hasExactSynonym "AIN457" @default.
- NCIT_C152315 hasExactSynonym "Cosentyx" @default.
- NCIT_C152315 hasExactSynonym "SECUKINUMAB" @default.
- NCIT_C152315 hasExactSynonym "Secukinumab" @default.
- NCIT_C152315 inSubset NCIT_C173381 @default.
- NCIT_C152315 inSubset NCIT_C173383 @default.
- NCIT_C152315 inSubset NCIT_C176424 @default.
- NCIT_C152315 inSubset NCIT_C63923 @default.
- NCIT_C152315 type Class @default.
- NCIT_C152315 isDefinedBy ncit.owl @default.
- NCIT_C152315 label "Secukinumab" @default.
- NCIT_C152315 subClassOf NCIT_C152315 @default.
- NCIT_C152315 subClassOf NCIT_C184322 @default.
- NCIT_C152315 subClassOf NCIT_C1908 @default.
- NCIT_C152315 subClassOf NCIT_C1909 @default.
- NCIT_C152315 subClassOf NCIT_C20401 @default.
- NCIT_C152315 subClassOf NCIT_C307 @default.
- NCIT_C152315 subClassOf NCIT_C308 @default.
- NCIT_C152315 subClassOf NCIT_C574 @default.