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- NCIT_C152489 IAO_0000115 "The succinate salt form of tafenoquine, an orally bioavailable 8-aminoquinoline derivative, with antimalarial activity. Although the mechanism is not completely understood, upon administration, tafenoquine inhibits the parasitic enzyme heme polymerase in the blood stages of the parasites. This inhibits the conversion of the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Tafenoquine is active against all the stages of Plasmodium species and is also active against the pre-erythrocytic liver stages of the parasites. This prevents the development of the erythrocytic forms of the parasite which are responsible for relapses in P. vivax malaria." @default.
- NCIT_C152489 NCIT_NHC0 "C152489" @default.
- NCIT_C152489 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152489 NCIT_P108 "Tafenoquine Succinate" @default.
- NCIT_C152489 NCIT_P208 "CL553693" @default.
- NCIT_C152489 NCIT_P210 "106635-81-8" @default.
- NCIT_C152489 NCIT_P319 "DL5J0B8VSS" @default.
- NCIT_C152489 NCIT_P322 "FDA" @default.
- NCIT_C152489 normalizedInformationContent "100" @default.
- NCIT_C152489 referenceCount "1" @default.
- NCIT_C152489 hasExactSynonym "Arakoda" @default.
- NCIT_C152489 hasExactSynonym "Krintafel" @default.
- NCIT_C152489 hasExactSynonym "TAFENOQUINE SUCCINATE" @default.
- NCIT_C152489 hasExactSynonym "Tafenoquine Succinate" @default.
- NCIT_C152489 inSubset NCIT_C173381 @default.
- NCIT_C152489 inSubset NCIT_C173383 @default.
- NCIT_C152489 inSubset NCIT_C63923 @default.
- NCIT_C152489 type Class @default.
- NCIT_C152489 isDefinedBy ncit.owl @default.
- NCIT_C152489 label "Tafenoquine Succinate" @default.
- NCIT_C152489 subClassOf NCIT_C152489 @default.
- NCIT_C152489 subClassOf NCIT_C1908 @default.
- NCIT_C152489 subClassOf NCIT_C1909 @default.
- NCIT_C152489 subClassOf NCIT_C254 @default.
- NCIT_C152489 subClassOf NCIT_C271 @default.
- NCIT_C152489 subClassOf NCIT_C276 @default.
- NCIT_C152489 subClassOf NCIT_C277 @default.