Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C152494> ?p ?o ?g. }
Showing items 1 to 43 of
43
with 100 items per page.
- NCIT_C152494 IAO_0000115 "The tosylate salt form of talazoparib, an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Upon administration, talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks." @default.
- NCIT_C152494 NCIT_A7 NCIT_C104720 @default.
- NCIT_C152494 NCIT_A7 NCIT_C48215 @default.
- NCIT_C152494 NCIT_NHC0 "C152494" @default.
- NCIT_C152494 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152494 NCIT_P107 "Talazoparib Tosylate" @default.
- NCIT_C152494 NCIT_P108 "Talazoparib Tosylate" @default.
- NCIT_C152494 NCIT_P208 "CL553698" @default.
- NCIT_C152494 NCIT_P210 "1373431-65-2" @default.
- NCIT_C152494 NCIT_P319 "02WK9U5NZC" @default.
- NCIT_C152494 NCIT_P322 "CTRP" @default.
- NCIT_C152494 NCIT_P322 "FDA" @default.
- NCIT_C152494 NCIT_P329 "694964" @default.
- NCIT_C152494 NCIT_P330 "694964" @default.
- NCIT_C152494 NCIT_P399 "694964" @default.
- NCIT_C152494 NCIT_R146 NCIT_C104101 @default.
- NCIT_C152494 NCIT_R146 NCIT_C16554 @default.
- NCIT_C152494 NCIT_R146 NCIT_C17021 @default.
- NCIT_C152494 NCIT_R146 NCIT_C17210 @default.
- NCIT_C152494 NCIT_R146 NCIT_C17434 @default.
- NCIT_C152494 NCIT_R146 NCIT_C20027 @default.
- NCIT_C152494 NCIT_R146 NCIT_C21170 @default.
- NCIT_C152494 NCIT_R146 NCIT_C26548 @default.
- NCIT_C152494 NCIT_R146 NCIT_C48215 @default.
- NCIT_C152494 normalizedInformationContent "100" @default.
- NCIT_C152494 referenceCount "1" @default.
- NCIT_C152494 hasExactSynonym "TALAZOPARIB TOSYLATE" @default.
- NCIT_C152494 hasExactSynonym "Talazoparib Tosylate" @default.
- NCIT_C152494 hasExactSynonym "Talzenna" @default.
- NCIT_C152494 inSubset NCIT_C116977 @default.
- NCIT_C152494 inSubset NCIT_C116978 @default.
- NCIT_C152494 inSubset NCIT_C176424 @default.
- NCIT_C152494 inSubset NCIT_C63923 @default.
- NCIT_C152494 type Class @default.
- NCIT_C152494 isDefinedBy ncit.owl @default.
- NCIT_C152494 label "Talazoparib Tosylate" @default.
- NCIT_C152494 subClassOf NCIT_C152494 @default.
- NCIT_C152494 subClassOf NCIT_C163758 @default.
- NCIT_C152494 subClassOf NCIT_C1908 @default.
- NCIT_C152494 subClassOf NCIT_C1909 @default.
- NCIT_C152494 subClassOf NCIT_C274 @default.
- NCIT_C152494 subClassOf NCIT_C471 @default.
- NCIT_C152494 subClassOf NCIT_C62554 @default.