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- NCIT_C152632 IAO_0000115 "A proprietary synthetic oligonucleotide-based agonist of toll-like receptor 9 (TLR9), with potential immunostimulating activity. Upon administration, tilsotolimod binds to and activates TLR9 expressed by plasmacytoid dendritic cells (pDCs) and B-cells. This initiates immune signaling pathways, activates B-cells and pDCs, and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity." @default.
- NCIT_C152632 NCIT_A5 NCIT_C125080 @default.
- NCIT_C152632 NCIT_A7 NCIT_C96048 @default.
- NCIT_C152632 NCIT_NHC0 "C152632" @default.
- NCIT_C152632 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152632 NCIT_P107 "Tilsotolimod" @default.
- NCIT_C152632 NCIT_P108 "Tilsotolimod" @default.
- NCIT_C152632 NCIT_P208 "CL553836" @default.
- NCIT_C152632 NCIT_P210 "1948266-37-2" @default.
- NCIT_C152632 NCIT_P319 "G287IC9MH3" @default.
- NCIT_C152632 NCIT_P322 "CTRP" @default.
- NCIT_C152632 NCIT_P322 "FDA" @default.
- NCIT_C152632 normalizedInformationContent "100" @default.
- NCIT_C152632 referenceCount "1" @default.
- NCIT_C152632 hasExactSynonym "TILSOTOLIMOD" @default.
- NCIT_C152632 hasExactSynonym "Tilsotolimod" @default.
- NCIT_C152632 inSubset NCIT_C116977 @default.
- NCIT_C152632 inSubset NCIT_C116978 @default.
- NCIT_C152632 inSubset NCIT_C63923 @default.
- NCIT_C152632 type Class @default.
- NCIT_C152632 isDefinedBy ncit.owl @default.
- NCIT_C152632 label "Tilsotolimod" @default.
- NCIT_C152632 subClassOf NCIT_C152632 @default.
- NCIT_C152632 subClassOf NCIT_C177174 @default.
- NCIT_C152632 subClassOf NCIT_C177175 @default.
- NCIT_C152632 subClassOf NCIT_C1908 @default.
- NCIT_C152632 subClassOf NCIT_C1909 @default.
- NCIT_C152632 subClassOf NCIT_C2139 @default.
- NCIT_C152632 subClassOf NCIT_C308 @default.