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- NCIT_C152666 IAO_0000115 "The hydrochloride salt of tivozanib, an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis." @default.
- NCIT_C152666 NCIT_A6 NCIT_C85444 @default.
- NCIT_C152666 NCIT_NHC0 "C152666" @default.
- NCIT_C152666 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152666 NCIT_P107 "Tivozanib Hydrochloride" @default.
- NCIT_C152666 NCIT_P108 "Tivozanib Hydrochloride" @default.
- NCIT_C152666 NCIT_P208 "CL553998" @default.
- NCIT_C152666 NCIT_P210 "682745-41-1" @default.
- NCIT_C152666 NCIT_P302 "adult patients with relapsed or refractory advanced renal cell carcinoma (RCC)" @default.
- NCIT_C152666 NCIT_P319 "8A9H4VK35Z" @default.
- NCIT_C152666 NCIT_P322 "CTRP" @default.
- NCIT_C152666 NCIT_P322 "FDA" @default.
- NCIT_C152666 NCIT_P329 "561728" @default.
- NCIT_C152666 NCIT_P330 "561728" @default.
- NCIT_C152666 NCIT_P399 "561728" @default.
- NCIT_C152666 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C152666 referenceCount "2" @default.
- NCIT_C152666 hasExactSynonym "Fotivda" @default.
- NCIT_C152666 hasExactSynonym "TIVOZANIB HYDROCHLORIDE" @default.
- NCIT_C152666 hasExactSynonym "Tivozanib Hydrochloride Hydrate" @default.
- NCIT_C152666 hasExactSynonym "Tivozanib Hydrochloride" @default.
- NCIT_C152666 hasExactSynonym "Tivozanib Monohydrochloride Monohydrate" @default.
- NCIT_C152666 inSubset NCIT_C116977 @default.
- NCIT_C152666 inSubset NCIT_C116978 @default.
- NCIT_C152666 inSubset NCIT_C176424 @default.
- NCIT_C152666 inSubset NCIT_C63923 @default.
- NCIT_C152666 type Class @default.
- NCIT_C152666 isDefinedBy ncit.owl @default.
- NCIT_C152666 label "Tivozanib Hydrochloride" @default.
- NCIT_C152666 subClassOf NCIT_C1404 @default.
- NCIT_C152666 subClassOf NCIT_C152666 @default.
- NCIT_C152666 subClassOf NCIT_C163758 @default.
- NCIT_C152666 subClassOf NCIT_C163953 @default.
- NCIT_C152666 subClassOf NCIT_C1742 @default.
- NCIT_C152666 subClassOf NCIT_C1908 @default.
- NCIT_C152666 subClassOf NCIT_C1909 @default.
- NCIT_C152666 subClassOf NCIT_C1967 @default.
- NCIT_C152666 subClassOf NCIT_C274 @default.
- NCIT_C152666 subClassOf NCIT_C471 @default.
- NCIT_C152666 subClassOf NCIT_C93259 @default.