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- NCIT_C152692 IAO_0000115 "A glycoengineered second-generation antibody of cetuximab with potential antineoplastic activities. Upon intravenous administration, tomuzotuximab selectively binds to the extracellular domain of the epidermal growth factor receptor (EGFR), thereby preventing the activation and subsequent dimerization of the receptor. This may prevent EGFR-mediated signaling and inhibit EGFR-dependent tumor cell proliferation. Further, tomuzotuximab has a fully human glycosylation pattern and is glyco-optimized at its Fc domain to promote antibody-dependent cell-mediated cytotoxicity (ADCC). EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of certain tumor types." @default.
- NCIT_C152692 NCIT_A7 NCIT_C17068 @default.
- NCIT_C152692 NCIT_NHC0 "C152692" @default.
- NCIT_C152692 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C152692 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152692 NCIT_P108 "Tomuzotuximab" @default.
- NCIT_C152692 NCIT_P208 "CL554024" @default.
- NCIT_C152692 NCIT_P210 "1646321-00-7" @default.
- NCIT_C152692 NCIT_P319 "5P637IXG16" @default.
- NCIT_C152692 NCIT_P322 "FDA" @default.
- NCIT_C152692 NCIT_P329 "794657" @default.
- NCIT_C152692 NCIT_P330 "794657" @default.
- NCIT_C152692 NCIT_P399 "794657" @default.
- NCIT_C152692 NCIT_R124 NCIT_C17710 @default.
- NCIT_C152692 NCIT_R124 NCIT_C17828 @default.
- NCIT_C152692 NCIT_R124 NCIT_C18219 @default.
- NCIT_C152692 NCIT_R124 NCIT_C19986 @default.
- NCIT_C152692 NCIT_R124 NCIT_C40474 @default.
- NCIT_C152692 normalizedInformationContent "100" @default.
- NCIT_C152692 referenceCount "1" @default.
- NCIT_C152692 hasExactSynonym "TOMUZOTUXIMAB" @default.
- NCIT_C152692 hasExactSynonym "Tomuzotuximab" @default.
- NCIT_C152692 inSubset NCIT_C176424 @default.
- NCIT_C152692 inSubset NCIT_C63923 @default.
- NCIT_C152692 type Class @default.
- NCIT_C152692 isDefinedBy ncit.owl @default.
- NCIT_C152692 label "Tomuzotuximab" @default.
- NCIT_C152692 subClassOf NCIT_C133878 @default.
- NCIT_C152692 subClassOf NCIT_C152692 @default.
- NCIT_C152692 subClassOf NCIT_C163758 @default.
- NCIT_C152692 subClassOf NCIT_C163952 @default.
- NCIT_C152692 subClassOf NCIT_C1908 @default.
- NCIT_C152692 subClassOf NCIT_C1909 @default.
- NCIT_C152692 subClassOf NCIT_C20401 @default.
- NCIT_C152692 subClassOf NCIT_C274 @default.
- NCIT_C152692 subClassOf NCIT_C307 @default.
- NCIT_C152692 subClassOf NCIT_C308 @default.