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- NCIT_C152795 IAO_0000115 "The tosylate form of umbralisib, an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. umbralisib inhibits PI3K and prevents the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in tumor cells and cells of the hematopoietic lineage. The targeted inhibition of PI3K-delta allows for PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival." @default.
- NCIT_C152795 NCIT_A7 NCIT_C113631 @default.
- NCIT_C152795 NCIT_NHC0 "C152795" @default.
- NCIT_C152795 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152795 NCIT_P107 "Umbralisib Tosylate" @default.
- NCIT_C152795 NCIT_P108 "Umbralisib Tosylate" @default.
- NCIT_C152795 NCIT_P208 "CL554127" @default.
- NCIT_C152795 NCIT_P210 "1532533-72-4" @default.
- NCIT_C152795 NCIT_P302 "Adult patients with relapsed or refractory marginal zone lymphoma (MZL) who have received at least one prior anti-CD20-based regimen;; Adult patients with relapsed or refractory follicular lymphoma (FL) who have received at least three prior lines of systemic therapy." @default.
- NCIT_C152795 NCIT_P319 "FU8XW5V3FS" @default.
- NCIT_C152795 NCIT_P322 "CTRP" @default.
- NCIT_C152795 NCIT_P322 "FDA" @default.
- NCIT_C152795 NCIT_P322 "GDC" @default.
- NCIT_C152795 NCIT_P329 "745293" @default.
- NCIT_C152795 NCIT_P330 "745293" @default.
- NCIT_C152795 NCIT_P399 "803975" @default.
- NCIT_C152795 normalizedInformationContent "100" @default.
- NCIT_C152795 referenceCount "1" @default.
- NCIT_C152795 hasExactSynonym "UMBRALISIB TOSYLATE" @default.
- NCIT_C152795 hasExactSynonym "Ukoniq" @default.
- NCIT_C152795 hasExactSynonym "Umbralisib Tosylate" @default.
- NCIT_C152795 inSubset NCIT_C116977 @default.
- NCIT_C152795 inSubset NCIT_C116978 @default.
- NCIT_C152795 inSubset NCIT_C128784 @default.
- NCIT_C152795 inSubset NCIT_C157711 @default.
- NCIT_C152795 inSubset NCIT_C157712 @default.
- NCIT_C152795 inSubset NCIT_C176424 @default.
- NCIT_C152795 inSubset NCIT_C63923 @default.
- NCIT_C152795 type Class @default.
- NCIT_C152795 isDefinedBy ncit.owl @default.
- NCIT_C152795 label "Umbralisib Tosylate" @default.
- NCIT_C152795 subClassOf NCIT_C129824 @default.
- NCIT_C152795 subClassOf NCIT_C129825 @default.
- NCIT_C152795 subClassOf NCIT_C1404 @default.
- NCIT_C152795 subClassOf NCIT_C152795 @default.
- NCIT_C152795 subClassOf NCIT_C163758 @default.
- NCIT_C152795 subClassOf NCIT_C1742 @default.
- NCIT_C152795 subClassOf NCIT_C1908 @default.
- NCIT_C152795 subClassOf NCIT_C1909 @default.
- NCIT_C152795 subClassOf NCIT_C2152 @default.
- NCIT_C152795 subClassOf NCIT_C2189 @default.
- NCIT_C152795 subClassOf NCIT_C274 @default.
- NCIT_C152795 subClassOf NCIT_C471 @default.