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- NCIT_C152811 IAO_0000115 "An orally bioavailable, hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor (HIF-PHI), with potential anti-anemic and anti-inflammatory activities. Upon administration, vadadustat binds to and inhibits HIF-PH, an enzyme responsible for the degradation of transcription factors in the HIF family under normal oxygen conditions. This prevents HIF breakdown and promotes HIF activity. Increased HIF activity leads to an increase in endogenous erythropoietin production, thereby enhancing erythropoiesis. It also reduces the expression of the peptide hormone hepcidin, improves iron availability, and boosts hemoglobin (Hb) levels. HIF regulates the expression of genes in response to reduced oxygen levels, including genes required for erythropoiesis and iron metabolism. In addition, HIF 1-alpha (HIF1A) may play a role in reducing inflammation during acute lung injury (ALI) through HIF-dependent control of glucose metabolism in the alveolar epithelium." @default.
- NCIT_C152811 NCIT_NHC0 "C152811" @default.
- NCIT_C152811 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152811 NCIT_P108 "Vadadustat" @default.
- NCIT_C152811 NCIT_P208 "CL554143" @default.
- NCIT_C152811 NCIT_P210 "1000025-07-9" @default.
- NCIT_C152811 NCIT_P319 "I60W9520VV" @default.
- NCIT_C152811 NCIT_P322 "FDA" @default.
- NCIT_C152811 normalizedInformationContent "100" @default.
- NCIT_C152811 referenceCount "1" @default.
- NCIT_C152811 hasExactSynonym "AKB 6548" @default.
- NCIT_C152811 hasExactSynonym "AKB-6548" @default.
- NCIT_C152811 hasExactSynonym "AKB6548" @default.
- NCIT_C152811 hasExactSynonym "VADADUSTAT" @default.
- NCIT_C152811 hasExactSynonym "Vadadustat" @default.
- NCIT_C152811 inSubset NCIT_C173381 @default.
- NCIT_C152811 inSubset NCIT_C173383 @default.
- NCIT_C152811 inSubset NCIT_C63923 @default.
- NCIT_C152811 type Class @default.
- NCIT_C152811 isDefinedBy ncit.owl @default.
- NCIT_C152811 label "Vadadustat" @default.
- NCIT_C152811 subClassOf NCIT_C152811 @default.
- NCIT_C152811 subClassOf NCIT_C1908 @default.
- NCIT_C152811 subClassOf NCIT_C1909 @default.
- NCIT_C152811 subClassOf NCIT_C471 @default.
- NCIT_C152811 subClassOf NCIT_C78275 @default.