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- NCIT_C152862 IAO_0000115 "An orally bioavailable stimulator of soluble guanylate cyclase (sGC), with vasodilating activity. Upon oral administration, vericiguat directly stimulates the catalytic activity of sGC and increases the formation of the intracellular second messenger cyclic guanosine monophosphate (cGMP), which is derived from guanosine triphosphate (GTP). This results in smooth muscle relaxation and vasodilation. sGC, a heme-containing cytoplasmic signaling enzyme, catalyzes the formation of cGMP from GTP in response to nitric oxide (NO) binding to heme. Vericiguat stimulates sGC independently of and synergistically with NO." @default.
- NCIT_C152862 NCIT_NHC0 "C152862" @default.
- NCIT_C152862 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152862 NCIT_P107 "Vericiguat" @default.
- NCIT_C152862 NCIT_P108 "Vericiguat" @default.
- NCIT_C152862 NCIT_P208 "CL554066" @default.
- NCIT_C152862 NCIT_P210 "1350653-20-1" @default.
- NCIT_C152862 NCIT_P319 "LV66ADM269" @default.
- NCIT_C152862 NCIT_P322 "CTRP" @default.
- NCIT_C152862 NCIT_P322 "FDA" @default.
- NCIT_C152862 NCIT_P399 "813005" @default.
- NCIT_C152862 normalizedInformationContent "100" @default.
- NCIT_C152862 referenceCount "1" @default.
- NCIT_C152862 hasExactSynonym "BAY-1021189" @default.
- NCIT_C152862 hasExactSynonym "MK-1242" @default.
- NCIT_C152862 hasExactSynonym "VERICIGUAT" @default.
- NCIT_C152862 hasExactSynonym "Vericiguat" @default.
- NCIT_C152862 hasExactSynonym "Verquvo" @default.
- NCIT_C152862 inSubset NCIT_C116977 @default.
- NCIT_C152862 inSubset NCIT_C116978 @default.
- NCIT_C152862 inSubset NCIT_C176424 @default.
- NCIT_C152862 inSubset NCIT_C63923 @default.
- NCIT_C152862 type Class @default.
- NCIT_C152862 isDefinedBy ncit.owl @default.
- NCIT_C152862 label "Vericiguat" @default.
- NCIT_C152862 subClassOf NCIT_C152862 @default.
- NCIT_C152862 subClassOf NCIT_C1908 @default.
- NCIT_C152862 subClassOf NCIT_C1909 @default.
- NCIT_C152862 subClassOf NCIT_C29707 @default.
- NCIT_C152862 subClassOf NCIT_C78274 @default.