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- NCIT_C152914 IAO_0000115 "An orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. Upon administration, vorasidenib specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH mutations. In addition, vorasidenib is able to penetrate the blood-brain barrier (BBB). IDH1 and 2, metabolic enzymes that catalyze the conversion of isocitrate into a-KG, play key roles in energy production and are mutated in a variety of cancer cell types. In addition, mutant forms of IDH1 and 2 catalyze the formation of 2HG and drive cancer growth by blocking cellular differentiation and inducing cellular proliferation." @default.
- NCIT_C152914 NCIT_A32 NCIT_C1909 @default.
- NCIT_C152914 NCIT_A7 NCIT_C77217 @default.
- NCIT_C152914 NCIT_A7 NCIT_C84990 @default.
- NCIT_C152914 NCIT_NHC0 "C152914" @default.
- NCIT_C152914 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152914 NCIT_P107 "Vorasidenib" @default.
- NCIT_C152914 NCIT_P108 "Vorasidenib" @default.
- NCIT_C152914 NCIT_P207 "C4053681" @default.
- NCIT_C152914 NCIT_P210 "1644545-52-7" @default.
- NCIT_C152914 NCIT_P319 "789Q85GA8P" @default.
- NCIT_C152914 NCIT_P322 "CTRP" @default.
- NCIT_C152914 NCIT_P322 "FDA" @default.
- NCIT_C152914 NCIT_P322 "GDC" @default.
- NCIT_C152914 NCIT_P329 "774431" @default.
- NCIT_C152914 NCIT_P330 "774431" @default.
- NCIT_C152914 NCIT_P375 "Pan-IDH Mutant Inhibitor AG-881" @default.
- NCIT_C152914 NCIT_P375 "Vorasidenib" @default.
- NCIT_C152914 NCIT_P399 "774431" @default.
- NCIT_C152914 normalizedInformationContent "100" @default.
- NCIT_C152914 referenceCount "1" @default.
- NCIT_C152914 hasExactSynonym "AG 881" @default.
- NCIT_C152914 hasExactSynonym "AG-881" @default.
- NCIT_C152914 hasExactSynonym "AG881" @default.
- NCIT_C152914 hasExactSynonym "VORASIDENIB" @default.
- NCIT_C152914 hasExactSynonym "Vorasidenib" @default.
- NCIT_C152914 inSubset NCIT_C116977 @default.
- NCIT_C152914 inSubset NCIT_C116978 @default.
- NCIT_C152914 inSubset NCIT_C128784 @default.
- NCIT_C152914 inSubset NCIT_C157711 @default.
- NCIT_C152914 inSubset NCIT_C157712 @default.
- NCIT_C152914 inSubset NCIT_C176424 @default.
- NCIT_C152914 inSubset NCIT_C177537 @default.
- NCIT_C152914 inSubset NCIT_C63923 @default.
- NCIT_C152914 type Class @default.
- NCIT_C152914 isDefinedBy ncit.owl @default.
- NCIT_C152914 label "Vorasidenib" @default.
- NCIT_C152914 subClassOf NCIT_C129824 @default.
- NCIT_C152914 subClassOf NCIT_C129825 @default.
- NCIT_C152914 subClassOf NCIT_C137826 @default.
- NCIT_C152914 subClassOf NCIT_C152914 @default.
- NCIT_C152914 subClassOf NCIT_C163758 @default.
- NCIT_C152914 subClassOf NCIT_C1908 @default.
- NCIT_C152914 subClassOf NCIT_C1909 @default.
- NCIT_C152914 subClassOf NCIT_C2189 @default.
- NCIT_C152914 subClassOf NCIT_C274 @default.
- NCIT_C152914 subClassOf NCIT_C471 @default.