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- NCIT_C152922 IAO_0000115 "An orally bioavailable inhibitor of the hepatitis C virus (HCV) non-structural protein 3/non-structural protein 4A (NS3/NS4A) serine protease, with antiviral activity. Upon administration, voxilaprevir binds to the HCV NS3/NS4A serine protease and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts both the processing of viral proteins and the formation of the viral replication complex, thereby preventing viral replication and function. NS3, a serine protease, is essential for the proteolytic cleavage of multiple sites within the HCV polyprotein and plays a key role during HCV ribonucleic acid (RNA) replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family; HCV infection is associated with the development of hepatocellular carcinoma (HCC)." @default.
- NCIT_C152922 NCIT_NHC0 "C152922" @default.
- NCIT_C152922 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152922 NCIT_P107 "Voxilaprevir" @default.
- NCIT_C152922 NCIT_P108 "Voxilaprevir" @default.
- NCIT_C152922 NCIT_P208 "CL554253" @default.
- NCIT_C152922 NCIT_P210 "1535212-07-7" @default.
- NCIT_C152922 NCIT_P319 "0570F37359" @default.
- NCIT_C152922 NCIT_P322 "CTRP" @default.
- NCIT_C152922 NCIT_P322 "FDA" @default.
- NCIT_C152922 NCIT_P329 "798441" @default.
- NCIT_C152922 NCIT_P330 "798441" @default.
- NCIT_C152922 NCIT_P399 "798441" @default.
- NCIT_C152922 normalizedInformationContent "100" @default.
- NCIT_C152922 referenceCount "1" @default.
- NCIT_C152922 hasExactSynonym "GS 9857" @default.
- NCIT_C152922 hasExactSynonym "GS-9857" @default.
- NCIT_C152922 hasExactSynonym "GS9857" @default.
- NCIT_C152922 hasExactSynonym "VOXILAPREVIR" @default.
- NCIT_C152922 hasExactSynonym "Voxilaprevir" @default.
- NCIT_C152922 inSubset NCIT_C116977 @default.
- NCIT_C152922 inSubset NCIT_C116978 @default.
- NCIT_C152922 inSubset NCIT_C176424 @default.
- NCIT_C152922 inSubset NCIT_C63923 @default.
- NCIT_C152922 type Class @default.
- NCIT_C152922 isDefinedBy ncit.owl @default.
- NCIT_C152922 label "Voxilaprevir" @default.
- NCIT_C152922 subClassOf NCIT_C152922 @default.
- NCIT_C152922 subClassOf NCIT_C1908 @default.
- NCIT_C152922 subClassOf NCIT_C1909 @default.
- NCIT_C152922 subClassOf NCIT_C254 @default.
- NCIT_C152922 subClassOf NCIT_C281 @default.
- NCIT_C152922 subClassOf NCIT_C471 @default.
- NCIT_C152922 subClassOf NCIT_C783 @default.