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- NCIT_C152948 IAO_0000115 "A full-length IgG1 bispecific antibody with enhanced antibody-dependent cellular cytotoxicity (ADCC) directed against human epidermal growth factor receptor 2 (HER2; EGFR2, ERBB2) and human epidermal growth factor receptor 3 (HER3; ErbB3), with potential antineoplastic activity. Upon intravenous administration of zenocutuzumab, the bispecific antibody docks on HER2, and subsequently blocks heregulin-stimulated proliferation of tumor cells by binding HER3. In addition to inhibiting HER3-dependent signaling, simultaneous targeting of HER2 and HER3 by zenocutuzumab may overcome a common resistance mechanism driven by heregulin-mediated dimerization of HER2 and HER3. Zenocutuzumab is expected to eliminate tumor cells by recruiting natural killer (NK) cells to tumor cells coated with the bispecific antibody." @default.
- NCIT_C152948 NCIT_A32 NCIT_C1909 @default.
- NCIT_C152948 NCIT_A7 NCIT_C17319 @default.
- NCIT_C152948 NCIT_A7 NCIT_C18490 @default.
- NCIT_C152948 NCIT_NHC0 "C152948" @default.
- NCIT_C152948 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C152948 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C152948 NCIT_P107 "Zenocutuzumab" @default.
- NCIT_C152948 NCIT_P108 "Zenocutuzumab" @default.
- NCIT_C152948 NCIT_P208 "CL554279" @default.
- NCIT_C152948 NCIT_P210 "1969309-56-5" @default.
- NCIT_C152948 NCIT_P319 "AE72RB1W1X" @default.
- NCIT_C152948 NCIT_P322 "CTRP" @default.
- NCIT_C152948 NCIT_P322 "FDA" @default.
- NCIT_C152948 NCIT_P322 "GDC" @default.
- NCIT_C152948 NCIT_P329 "794043" @default.
- NCIT_C152948 NCIT_P330 "794043" @default.
- NCIT_C152948 NCIT_P375 "Anti-HER2/Anti-HER3 Bispecific Monoclonal Antibody MCLA-128" @default.
- NCIT_C152948 NCIT_P399 "794043" @default.
- NCIT_C152948 NCIT_R124 NCIT_C17710 @default.
- NCIT_C152948 NCIT_R124 NCIT_C17828 @default.
- NCIT_C152948 NCIT_R124 NCIT_C18219 @default.
- NCIT_C152948 NCIT_R124 NCIT_C19986 @default.
- NCIT_C152948 NCIT_R124 NCIT_C40474 @default.
- NCIT_C152948 normalizedInformationContent "100" @default.
- NCIT_C152948 referenceCount "1" @default.
- NCIT_C152948 hasExactSynonym "Anti-HER2 x Anti-HER3 Bispecific Monoclonal Antibody MCLA-128" @default.
- NCIT_C152948 hasExactSynonym "Anti-HER2/Anti-HER3 Bispecific Monoclonal Antibody MCLA-128" @default.
- NCIT_C152948 hasExactSynonym "MCLA 128" @default.
- NCIT_C152948 hasExactSynonym "MCLA-128" @default.
- NCIT_C152948 hasExactSynonym "MCLA128" @default.
- NCIT_C152948 hasExactSynonym "ZENOCUTUZUMAB" @default.
- NCIT_C152948 hasExactSynonym "Zenocutuzumab" @default.
- NCIT_C152948 inSubset NCIT_C116977 @default.
- NCIT_C152948 inSubset NCIT_C116978 @default.
- NCIT_C152948 inSubset NCIT_C128784 @default.
- NCIT_C152948 inSubset NCIT_C157711 @default.
- NCIT_C152948 inSubset NCIT_C157712 @default.
- NCIT_C152948 inSubset NCIT_C176424 @default.
- NCIT_C152948 inSubset NCIT_C177537 @default.
- NCIT_C152948 inSubset NCIT_C63923 @default.
- NCIT_C152948 type Class @default.
- NCIT_C152948 isDefinedBy ncit.owl @default.
- NCIT_C152948 label "Zenocutuzumab" @default.
- NCIT_C152948 subClassOf NCIT_C129821 @default.
- NCIT_C152948 subClassOf NCIT_C129822 @default.
- NCIT_C152948 subClassOf NCIT_C1454 @default.
- NCIT_C152948 subClassOf NCIT_C152948 @default.
- NCIT_C152948 subClassOf NCIT_C155711 @default.
- NCIT_C152948 subClassOf NCIT_C163758 @default.
- NCIT_C152948 subClassOf NCIT_C163760 @default.
- NCIT_C152948 subClassOf NCIT_C1908 @default.
- NCIT_C152948 subClassOf NCIT_C1909 @default.
- NCIT_C152948 subClassOf NCIT_C199383 @default.
- NCIT_C152948 subClassOf NCIT_C199386 @default.
- NCIT_C152948 subClassOf NCIT_C20401 @default.
- NCIT_C152948 subClassOf NCIT_C274 @default.
- NCIT_C152948 subClassOf NCIT_C28227 @default.
- NCIT_C152948 subClassOf NCIT_C307 @default.
- NCIT_C152948 subClassOf NCIT_C308 @default.