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- NCIT_C153094 IAO_0000115 "A therapeutic engineered DNA vaccine composed of DNA sequences encoding for one or more tetanus toxoid peptides and the oncoprotein MYB, with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, TetMYB is taken up and processed by dendritic cells (DCs), which present the processed antigen to the immune system. This activates cytotoxic T-lymphocytes (CTLs) and causes a CTL-mediated immune response against MYB-expressing tumor cells. MYB, an oncoprotein and transcription factor, is overexpressed in a variety of cancer types and is essential for tumor cell growth, inhibition of differentiation, and protection from apoptosis. Its expression is correlated with lower T-cell infiltration and poorer prognosis. As MYB is only weakly immunogenic, the tetanus toxoid peptides enhance the T-cell mediated immune responses against the MYB-expressing tumor cells." @default.
- NCIT_C153094 NCIT_NHC0 "C153094" @default.
- NCIT_C153094 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C153094 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C153094 NCIT_P108 "TetMYB DNA Vaccine" @default.
- NCIT_C153094 NCIT_P208 "CL554353" @default.
- NCIT_C153094 NCIT_P329 "793449" @default.
- NCIT_C153094 NCIT_P330 "793449" @default.
- NCIT_C153094 NCIT_P399 "793449" @default.
- NCIT_C153094 NCIT_R125 NCIT_C17828 @default.
- NCIT_C153094 NCIT_R125 NCIT_C17937 @default.
- NCIT_C153094 NCIT_R125 NCIT_C18095 @default.
- NCIT_C153094 NCIT_R125 NCIT_C18839 @default.
- NCIT_C153094 NCIT_R125 NCIT_C21124 @default.
- NCIT_C153094 NCIT_R125 NCIT_C40912 @default.
- NCIT_C153094 normalizedInformationContent "100" @default.
- NCIT_C153094 referenceCount "1" @default.
- NCIT_C153094 hasExactSynonym "DNA Vaccine TetMYB" @default.
- NCIT_C153094 hasExactSynonym "DNA-based TetMYB Vaccine" @default.
- NCIT_C153094 hasExactSynonym "TetMYB DNA Vaccine" @default.
- NCIT_C153094 hasExactSynonym "TetMYB Vaccine" @default.
- NCIT_C153094 hasExactSynonym "TetMYB" @default.
- NCIT_C153094 inSubset NCIT_C128784 @default.
- NCIT_C153094 inSubset NCIT_C176424 @default.
- NCIT_C153094 type Class @default.
- NCIT_C153094 isDefinedBy ncit.owl @default.
- NCIT_C153094 label "TetMYB DNA Vaccine" @default.
- NCIT_C153094 subClassOf B54964355300969fc5ef3ceed2feec186 @default.
- NCIT_C153094 subClassOf Be8eaa78829969a229e059ff88dc86413 @default.
- NCIT_C153094 subClassOf NCIT_C129820 @default.
- NCIT_C153094 subClassOf NCIT_C153094 @default.
- NCIT_C153094 subClassOf NCIT_C1663 @default.
- NCIT_C153094 subClassOf NCIT_C1908 @default.
- NCIT_C153094 subClassOf NCIT_C1909 @default.
- NCIT_C153094 subClassOf NCIT_C274 @default.
- NCIT_C153094 subClassOf NCIT_C307 @default.
- NCIT_C153094 subClassOf NCIT_C308 @default.
- NCIT_C153094 subClassOf NCIT_C39619 @default.
- NCIT_C153094 subClassOf NCIT_C923 @default.