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- NCIT_C153122 IAO_0000115 "An orally available and selective inhibitor of the receptor tyrosine kinases (RTKs) Axl (UFO) and Mer, with potential antineoplastic activity. Upon administration, INCB081776 targets and binds to both Axl and Mer, and prevents their activity. This blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells. Axl and Mer, both members of the TAM (Tyro3, Axl and Mer) family of RTKs, are overexpressed by many tumor cell types. They play key roles in tumor cell proliferation, survival, invasion, angiogenesis and metastasis, and their expression is associated with enhanced immunosuppression, drug resistance and poor prognosis." @default.
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- NCIT_C153122 NCIT_A7 NCIT_C26383 @default.
- NCIT_C153122 NCIT_NHC0 "C153122" @default.
- NCIT_C153122 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C153122 NCIT_P107 "Axl/Mer Inhibitor INCB081776" @default.
- NCIT_C153122 NCIT_P108 "Axl/Mer Inhibitor INCB081776" @default.
- NCIT_C153122 NCIT_P208 "CL554380" @default.
- NCIT_C153122 NCIT_P322 "CTRP" @default.
- NCIT_C153122 NCIT_P322 "GDC" @default.
- NCIT_C153122 NCIT_P329 "793938" @default.
- NCIT_C153122 NCIT_P330 "793938" @default.
- NCIT_C153122 NCIT_P366 "Axl/Mer Inhibitor INCB081776" @default.
- NCIT_C153122 NCIT_P375 "Axl/Mer Inhibitor INCB081776" @default.
- NCIT_C153122 NCIT_P399 "793938" @default.
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- NCIT_C153122 normalizedInformationContent "100" @default.
- NCIT_C153122 referenceCount "1" @default.
- NCIT_C153122 hasExactSynonym "Axl/Mer Inhibitor INCB081776" @default.
- NCIT_C153122 hasExactSynonym "INCB 081776" @default.
- NCIT_C153122 hasExactSynonym "INCB 81776" @default.
- NCIT_C153122 hasExactSynonym "INCB-081776" @default.
- NCIT_C153122 hasExactSynonym "INCB-81776" @default.
- NCIT_C153122 hasExactSynonym "INCB081776" @default.
- NCIT_C153122 hasExactSynonym "INCB81776" @default.
- NCIT_C153122 inSubset NCIT_C116977 @default.
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- NCIT_C153122 inSubset NCIT_C176424 @default.
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- NCIT_C153122 type Class @default.
- NCIT_C153122 isDefinedBy ncit.owl @default.
- NCIT_C153122 label "Axl/Mer Inhibitor INCB081776" @default.
- NCIT_C153122 subClassOf B05364db4c1299de6588b2698259c2a5f @default.
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- NCIT_C153122 subClassOf NCIT_C1404 @default.
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- NCIT_C153122 subClassOf NCIT_C274 @default.
- NCIT_C153122 subClassOf NCIT_C471 @default.