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- NCIT_C153130 IAO_0000115 "A bispecific molecule composed of a soluble, affinity-enhanced T-cell receptor (TCR) specific for human leukocyte antigen A2 (HLA-A2)-restricted cancer-testis antigens (CTAs) NY-ESO-1 and L antigen family member 1 isoform A (LAGE-1A; LAGE-A1; CT6.2a), fused to a single-chain variable fragment (scFv) specific for the T-cell surface antigen CD3, with potential immunomodulating and antineoplastic activities. Upon infusion, anti-NY-ESO1/LAGE-1A TCR/scFv anti-CD3 IMCnyeso specifically targets and binds with its TCR moiety to NY-ESO-1 and/or LAGE-1A expressed on tumor cells and with its scFv moiety to CD3 expressed on T-cells. This crosslinks tumor cells and T-cells, re-directs and activates T-cells, and results in a cytotoxic T-lymphocyte (CTL)-mediated destruction of NY-ESO-1 and/or LAGE-1A-positive tumor cells. NY-ESO-1 and LAGE-1A, members of the cancer-testis antigen (CTA) family, are overexpressed on the surface of various tumor cell types; they share a specific HLA-A*0201 epitope, 157-165, which is expressed on certain tumor cell types while its expression is not found on normal, healthy cells." @default.
- NCIT_C153130 NCIT_A32 NCIT_C1909 @default.
- NCIT_C153130 NCIT_A7 NCIT_C153125 @default.
- NCIT_C153130 NCIT_A7 NCIT_C39286 @default.
- NCIT_C153130 NCIT_NHC0 "C153130" @default.
- NCIT_C153130 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C153130 NCIT_P107 "Anti-NY-ESO1/LAGE-1A TCR/scFv Anti-CD3 IMCnyeso" @default.
- NCIT_C153130 NCIT_P108 "Anti-NY-ESO1/LAGE-1A TCR/scFv Anti-CD3 IMCnyeso" @default.
- NCIT_C153130 NCIT_P208 "CL554387" @default.
- NCIT_C153130 NCIT_P319 "C416JC9CX0" @default.
- NCIT_C153130 NCIT_P322 "CTRP" @default.
- NCIT_C153130 NCIT_P322 "FDA" @default.
- NCIT_C153130 NCIT_P322 "GDC" @default.
- NCIT_C153130 NCIT_P329 "793936" @default.
- NCIT_C153130 NCIT_P330 "793936" @default.
- NCIT_C153130 NCIT_P375 "Anti-NY-ESO1/LAGE-1A TCR/scFv Anti-CD3 IMCnyeso" @default.
- NCIT_C153130 NCIT_P399 "793936" @default.
- NCIT_C153130 normalizedInformationContent "100" @default.
- NCIT_C153130 referenceCount "1" @default.
- NCIT_C153130 hasExactSynonym "Anti-NY-ESO1/LAGE-1A TCR/scFv Anti-CD3 IMCnyeso" @default.
- NCIT_C153130 hasExactSynonym "Bispecific NY-ESO-1- and LAGE-1A-specific TCR/Anti-CD3" @default.
- NCIT_C153130 hasExactSynonym "HLA- A*0201-Restricted NY-ESO-1- and LAGE-1A-specific Soluble TCR/Anti-CD3 Bispecific Molecule" @default.
- NCIT_C153130 hasExactSynonym "IMCNYESO" @default.
- NCIT_C153130 hasExactSynonym "IMCnyeso" @default.
- NCIT_C153130 inSubset NCIT_C116977 @default.
- NCIT_C153130 inSubset NCIT_C116978 @default.
- NCIT_C153130 inSubset NCIT_C128784 @default.
- NCIT_C153130 inSubset NCIT_C157711 @default.
- NCIT_C153130 inSubset NCIT_C157712 @default.
- NCIT_C153130 inSubset NCIT_C176424 @default.
- NCIT_C153130 inSubset NCIT_C177537 @default.
- NCIT_C153130 inSubset NCIT_C63923 @default.
- NCIT_C153130 type Class @default.
- NCIT_C153130 isDefinedBy ncit.owl @default.
- NCIT_C153130 label "Anti-NY-ESO1/LAGE-1A TCR/scFv Anti-CD3 IMCnyeso" @default.
- NCIT_C153130 subClassOf NCIT_C129820 @default.
- NCIT_C153130 subClassOf NCIT_C153130 @default.
- NCIT_C153130 subClassOf NCIT_C1908 @default.
- NCIT_C153130 subClassOf NCIT_C1909 @default.
- NCIT_C153130 subClassOf NCIT_C274 @default.
- NCIT_C153130 subClassOf NCIT_C308 @default.