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- NCIT_C153133 IAO_0000115 "An aerosol inhalation formulation containing gemcitabine (GCB), a broad-spectrum antimetabolite and deoxycytidine analogue, with potential antineoplastic activity. Upon inhalation via a nebulizer, GCB is converted intracellularly by deoxycytidine kinase to its active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase (RNR), thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA, resulting in DNA strand termination and the induction of apoptosis of lung tumor cells. GCB administration directly into the lungs via aerosol yields higher concentrations of GCB locally than can be achieved by systemic GCB administration, potentially reducing systemic toxicity." @default.
- NCIT_C153133 NCIT_A32 NCIT_C1909 @default.
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- NCIT_C153133 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C153133 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C153133 NCIT_P107 "Aerosol Gemcitabine" @default.
- NCIT_C153133 NCIT_P108 "Aerosol Gemcitabine" @default.
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- NCIT_C153133 hasExactSynonym "Aerosol Gemcitabine" @default.
- NCIT_C153133 hasExactSynonym "Aerosolized GCB" @default.
- NCIT_C153133 hasExactSynonym "Aerosolized Gemcitabine" @default.
- NCIT_C153133 inSubset NCIT_C116977 @default.
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- NCIT_C153133 type Class @default.
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- NCIT_C153133 label "Aerosol Gemcitabine" @default.
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