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- NCIT_C153148 IAO_0000115 "An orally bioavailable stimulator of soluble guanylate cyclase (sGC), with potential anti-inflammatory and vasodilating activities. Upon oral administration, olinciguat targets, allosterically binds to and enhances the nitric oxide (NO)-dependent catalytic activity of sGC. This enhances NO-sGC signaling and increases the formation of the intracellular second messenger cyclic guanosine monophosphate (cGMP), which is derived from guanosine triphosphate (GTP). This enhances NO/cGMP-mediated muscle relaxation, suppresses leukocyte-endothelial interactions and promotes vascular anti-inflammatory effects. The NO/sGC/cGMP signaling pathway plays an important role in vasodilation, blood flow and inflammatory processes. sGC, a heme-containing cytoplasmic signaling enzyme, catalyzes the formation of cGMP from GTP in response to NO binding to heme." @default.
- NCIT_C153148 NCIT_NHC0 "C153148" @default.
- NCIT_C153148 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C153148 NCIT_P107 "Olinciguat" @default.
- NCIT_C153148 NCIT_P108 "Olinciguat" @default.
- NCIT_C153148 NCIT_P208 "CL554401" @default.
- NCIT_C153148 NCIT_P210 "1628732-62-6" @default.
- NCIT_C153148 NCIT_P319 "PD5F4ZXD21" @default.
- NCIT_C153148 NCIT_P322 "CTRP" @default.
- NCIT_C153148 NCIT_P322 "FDA" @default.
- NCIT_C153148 NCIT_P329 "793944" @default.
- NCIT_C153148 NCIT_P330 "793944" @default.
- NCIT_C153148 NCIT_P399 "793944" @default.
- NCIT_C153148 normalizedInformationContent "100" @default.
- NCIT_C153148 referenceCount "1" @default.
- NCIT_C153148 hasExactSynonym "IW 1701" @default.
- NCIT_C153148 hasExactSynonym "IW-1701" @default.
- NCIT_C153148 hasExactSynonym "IW1701" @default.
- NCIT_C153148 hasExactSynonym "OLINCIGUAT" @default.
- NCIT_C153148 hasExactSynonym "Olinciguat" @default.
- NCIT_C153148 hasExactSynonym "Soluble Guanylate Cyclase Stimulator IW-1701" @default.
- NCIT_C153148 hasExactSynonym "Stimulator of Soluble Guanylate Cyclase IW-1701" @default.
- NCIT_C153148 hasExactSynonym "sGC Stimulator IW-1701" @default.
- NCIT_C153148 inSubset NCIT_C116977 @default.
- NCIT_C153148 inSubset NCIT_C116978 @default.
- NCIT_C153148 inSubset NCIT_C176424 @default.
- NCIT_C153148 inSubset NCIT_C63923 @default.
- NCIT_C153148 type Class @default.
- NCIT_C153148 isDefinedBy ncit.owl @default.
- NCIT_C153148 label "Olinciguat" @default.
- NCIT_C153148 subClassOf NCIT_C153148 @default.
- NCIT_C153148 subClassOf NCIT_C1908 @default.
- NCIT_C153148 subClassOf NCIT_C1909 @default.
- NCIT_C153148 subClassOf NCIT_C78275 @default.