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- NCIT_C153215 IAO_0000115 "A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the B-cell-specific membrane protein CD19, and another that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/CD3 BiTE antibody AMG 562 binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the CD19 antigen expressed on malignant B-cells. This activates and redirects CTLs to CD19-expressing tumor cells, resulting in CTL-mediated killing of tumor cells. CD19 is a membrane antigen that is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages." @default.
- NCIT_C153215 NCIT_A32 NCIT_C1909 @default.
- NCIT_C153215 NCIT_A7 NCIT_C38894 @default.
- NCIT_C153215 NCIT_NHC0 "C153215" @default.
- NCIT_C153215 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C153215 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C153215 NCIT_P107 "Anti-CD19/CD3 BiTE Antibody AMG 562" @default.
- NCIT_C153215 NCIT_P108 "Anti-CD19/CD3 BiTE Antibody AMG 562" @default.
- NCIT_C153215 NCIT_P208 "CL554338" @default.
- NCIT_C153215 NCIT_P322 "CTRP" @default.
- NCIT_C153215 NCIT_P322 "GDC" @default.
- NCIT_C153215 NCIT_P329 "794049" @default.
- NCIT_C153215 NCIT_P330 "794049" @default.
- NCIT_C153215 NCIT_P375 "Anti-CD19/CD3 BiTE Antibody AMG 562" @default.
- NCIT_C153215 NCIT_P399 "794049" @default.
- NCIT_C153215 NCIT_R124 NCIT_C17710 @default.
- NCIT_C153215 NCIT_R124 NCIT_C17828 @default.
- NCIT_C153215 NCIT_R124 NCIT_C18219 @default.
- NCIT_C153215 NCIT_R124 NCIT_C19986 @default.
- NCIT_C153215 NCIT_R124 NCIT_C40474 @default.
- NCIT_C153215 normalizedInformationContent "100" @default.
- NCIT_C153215 referenceCount "1" @default.
- NCIT_C153215 hasExactSynonym "AMG 562" @default.
- NCIT_C153215 hasExactSynonym "AMG-562" @default.
- NCIT_C153215 hasExactSynonym "AMG562" @default.
- NCIT_C153215 hasExactSynonym "Anti-CD19/CD3 BiTE Antibody AMG 562" @default.
- NCIT_C153215 hasExactSynonym "BiTE Antibody AMG 562" @default.
- NCIT_C153215 hasExactSynonym "Bispecific T-cell Engager Antibody AMG 562" @default.
- NCIT_C153215 hasExactSynonym "CD19/CD3-directed Bispecific T-cell Engager Antibody AMG 562" @default.
- NCIT_C153215 inSubset NCIT_C116977 @default.
- NCIT_C153215 inSubset NCIT_C116978 @default.
- NCIT_C153215 inSubset NCIT_C128784 @default.
- NCIT_C153215 inSubset NCIT_C157711 @default.
- NCIT_C153215 inSubset NCIT_C157712 @default.
- NCIT_C153215 inSubset NCIT_C176424 @default.
- NCIT_C153215 inSubset NCIT_C177537 @default.
- NCIT_C153215 type Class @default.
- NCIT_C153215 isDefinedBy ncit.owl @default.
- NCIT_C153215 label "Anti-CD19/CD3 BiTE Antibody AMG 562" @default.
- NCIT_C153215 subClassOf NCIT_C112883 @default.
- NCIT_C153215 subClassOf NCIT_C112889 @default.
- NCIT_C153215 subClassOf NCIT_C129820 @default.
- NCIT_C153215 subClassOf NCIT_C129821 @default.
- NCIT_C153215 subClassOf NCIT_C129822 @default.
- NCIT_C153215 subClassOf NCIT_C1454 @default.
- NCIT_C153215 subClassOf NCIT_C153215 @default.
- NCIT_C153215 subClassOf NCIT_C163758 @default.
- NCIT_C153215 subClassOf NCIT_C1908 @default.
- NCIT_C153215 subClassOf NCIT_C1909 @default.
- NCIT_C153215 subClassOf NCIT_C198634 @default.
- NCIT_C153215 subClassOf NCIT_C201282 @default.
- NCIT_C153215 subClassOf NCIT_C20401 @default.
- NCIT_C153215 subClassOf NCIT_C274 @default.
- NCIT_C153215 subClassOf NCIT_C28227 @default.
- NCIT_C153215 subClassOf NCIT_C307 @default.
- NCIT_C153215 subClassOf NCIT_C308 @default.