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- NCIT_C153259 IAO_0000115 "An agonistic hexamer formation-enhanced mixture of two antibodies (HexaBody) that target two separate epitopes on death receptor type 5 (DR5; TNFRSF10B; tumor necrosis factor-related apoptosis-inducing ligand receptor 2; TRAILR2), with potential antineoplastic activity. Upon administration, tilogotamab specifically binds to and activates DR5. This results in the activation of caspase cascades and the induction of apoptosis in DR5-expressing tumor cells. DR5, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is involved in the promotion of caspase-dependent apoptosis. Compared to other DR5 antibody-based agonists, the antibodies in GEN1029 (DR5-01 and DR5-05) elicit increased receptor activation because they exhibit enhanced formation of antibody hexamers and receptor clusters at the cell surface due to E430G mutations in the Fc domains of both antibodies." @default.
- NCIT_C153259 NCIT_A32 NCIT_C1909 @default.
- NCIT_C153259 NCIT_A7 NCIT_C18178 @default.
- NCIT_C153259 NCIT_NHC0 "C153259" @default.
- NCIT_C153259 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C153259 NCIT_P107 "Tilogotamab" @default.
- NCIT_C153259 NCIT_P108 "Tilogotamab" @default.
- NCIT_C153259 NCIT_P208 "CL554487" @default.
- NCIT_C153259 NCIT_P210 "2109731-10-2" @default.
- NCIT_C153259 NCIT_P319 "1BU5EGF80S" @default.
- NCIT_C153259 NCIT_P322 "CTRP" @default.
- NCIT_C153259 NCIT_P322 "FDA" @default.
- NCIT_C153259 NCIT_P322 "GDC" @default.
- NCIT_C153259 NCIT_P329 "794053" @default.
- NCIT_C153259 NCIT_P330 "794053" @default.
- NCIT_C153259 NCIT_P375 "DR5 HexaBody Agonist GEN1029" @default.
- NCIT_C153259 NCIT_P375 "Tilogotamab" @default.
- NCIT_C153259 NCIT_P399 "794053" @default.
- NCIT_C153259 normalizedInformationContent "100" @default.
- NCIT_C153259 referenceCount "1" @default.
- NCIT_C153259 hasExactSynonym "DR5 HexaBody Agonist GEN1029" @default.
- NCIT_C153259 hasExactSynonym "GEN 1029" @default.
- NCIT_C153259 hasExactSynonym "GEN1029" @default.
- NCIT_C153259 hasExactSynonym "HexaBody-DR5-01/DR5-05" @default.
- NCIT_C153259 hasExactSynonym "HexaBody-DR5/DR5" @default.
- NCIT_C153259 hasExactSynonym "Hx-DR5-01/05" @default.
- NCIT_C153259 hasExactSynonym "TILOGOTAMAB" @default.
- NCIT_C153259 hasExactSynonym "Tilogotamab" @default.
- NCIT_C153259 inSubset NCIT_C116977 @default.
- NCIT_C153259 inSubset NCIT_C116978 @default.
- NCIT_C153259 inSubset NCIT_C128784 @default.
- NCIT_C153259 inSubset NCIT_C157711 @default.
- NCIT_C153259 inSubset NCIT_C157712 @default.
- NCIT_C153259 inSubset NCIT_C176424 @default.
- NCIT_C153259 inSubset NCIT_C177537 @default.
- NCIT_C153259 inSubset NCIT_C63923 @default.
- NCIT_C153259 type Class @default.
- NCIT_C153259 isDefinedBy ncit.owl @default.
- NCIT_C153259 label "Tilogotamab" @default.
- NCIT_C153259 subClassOf NCIT_C129821 @default.
- NCIT_C153259 subClassOf NCIT_C129822 @default.
- NCIT_C153259 subClassOf NCIT_C153259 @default.
- NCIT_C153259 subClassOf NCIT_C1908 @default.
- NCIT_C153259 subClassOf NCIT_C1909 @default.
- NCIT_C153259 subClassOf NCIT_C274 @default.
- NCIT_C153259 subClassOf NCIT_C307 @default.