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- NCIT_C153353 IAO_0000115 "A naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Upon administration, pterostilbene exerts its anti-oxidant activity by scavenging reactive oxygen species (ROS), thereby preventing oxidative stress and ROS-induced cell damage. It may also activate the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated pathway and increase the expression of various antioxidant enzymes, such as superoxide dismutase (SOD). In addition, pterostilbene is able to inhibit inflammation by reducing the expression of various inflammatory mediators, such as interleukin (IL) 1beta, tumor necrosis factor alpha (TNF-a), inducible nitric oxide synthase (iNOS), cyclooxygenases (COX), and nuclear factor kappa B (NF-kB). It also inhibits or prevents the activation of many signaling pathways involved in carcinogenesis, and increases expression of various tumor suppressor genes while decreasing expression of certain tumor promoting genes. It also directly induces apoptosis in tumor cells." @default.
- NCIT_C153353 NCIT_A32 NCIT_C1909 @default.
- NCIT_C153353 NCIT_NHC0 "C153353" @default.
- NCIT_C153353 NCIT_P106 "Organic Chemical" @default.
- NCIT_C153353 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C153353 NCIT_P107 "Pterostilbene" @default.
- NCIT_C153353 NCIT_P108 "Pterostilbene" @default.
- NCIT_C153353 NCIT_P207 "C0664965" @default.
- NCIT_C153353 NCIT_P210 "537-42-8" @default.
- NCIT_C153353 NCIT_P319 "26R60S6A5I" @default.
- NCIT_C153353 NCIT_P322 "CTRP" @default.
- NCIT_C153353 NCIT_P322 "FDA" @default.
- NCIT_C153353 NCIT_P322 "GDC" @default.
- NCIT_C153353 NCIT_P329 "794141" @default.
- NCIT_C153353 NCIT_P330 "794141" @default.
- NCIT_C153353 NCIT_P375 "Pterostilbene" @default.
- NCIT_C153353 NCIT_P399 "794141" @default.
- NCIT_C153353 normalizedInformationContent "100" @default.
- NCIT_C153353 referenceCount "1" @default.
- NCIT_C153353 hasExactSynonym "3',5'-Dimethoxy-4-stilbenol" @default.
- NCIT_C153353 hasExactSynonym "3,5-Dimethoxy-4'-hydroxystilbene" @default.
- NCIT_C153353 hasExactSynonym "PTEROSTILBENE" @default.
- NCIT_C153353 hasExactSynonym "Phenol, 4-(2-(3,5-Dimethoxyphenyl)ethenyl)-, (E)-" @default.
- NCIT_C153353 hasExactSynonym "Pterostilbene" @default.
- NCIT_C153353 hasExactSynonym "Trans-3,5-dimethoxy-4-hydroxystilbene" @default.
- NCIT_C153353 inSubset NCIT_C116977 @default.
- NCIT_C153353 inSubset NCIT_C116978 @default.
- NCIT_C153353 inSubset NCIT_C128784 @default.
- NCIT_C153353 inSubset NCIT_C157711 @default.
- NCIT_C153353 inSubset NCIT_C157712 @default.
- NCIT_C153353 inSubset NCIT_C176424 @default.
- NCIT_C153353 inSubset NCIT_C177537 @default.
- NCIT_C153353 inSubset NCIT_C63923 @default.
- NCIT_C153353 type Class @default.
- NCIT_C153353 isDefinedBy ncit.owl @default.
- NCIT_C153353 label "Pterostilbene" @default.
- NCIT_C153353 subClassOf NCIT_C153353 @default.
- NCIT_C153353 subClassOf NCIT_C1908 @default.
- NCIT_C153353 subClassOf NCIT_C1909 @default.
- NCIT_C153353 subClassOf NCIT_C26170 @default.
- NCIT_C153353 subClassOf NCIT_C275 @default.