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- NCIT_C153479 IAO_0000115 "An orally bioavailable, nucleoside analog and DNA methyltransferase I (DNMT1) inhibitor, with potential DNA hypomethylating and antineoplastic activities. Upon administration, 5-aza-4'-thio-2'-deoxycytidine (Aza-TdC) gets incorporated into DNA, where it binds to the active site of DNMT1, a maintenance methyltransferase that contributes to the hypermethylation and silencing of tumor suppressor genes. The formation of covalent DNMT1-DNA complexes inhibits DNMT1, prevents DNA methylation of CpG sites, causes CpG demethylation, and results in the re-expression and re-activation of silenced tumor suppressor genes. This inhibits tumor cell proliferation. DNMT1, overactivated in tumor cells, plays a key role in tumor cell proliferation." @default.
- NCIT_C153479 NCIT_A32 NCIT_C1909 @default.
- NCIT_C153479 NCIT_NHC0 "C153479" @default.
- NCIT_C153479 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C153479 NCIT_P107 "5-Aza-4'-thio-2'-deoxycytidine" @default.
- NCIT_C153479 NCIT_P108 "5-Aza-4'-thio-2'-deoxycytidine" @default.
- NCIT_C153479 NCIT_P175 "777586" @default.
- NCIT_C153479 NCIT_P208 "CL554978" @default.
- NCIT_C153479 NCIT_P210 "169514-76-5" @default.
- NCIT_C153479 NCIT_P319 "U2PTN0RZF6" @default.
- NCIT_C153479 NCIT_P322 "CTRP" @default.
- NCIT_C153479 NCIT_P322 "FDA" @default.
- NCIT_C153479 NCIT_P322 "GDC" @default.
- NCIT_C153479 NCIT_P329 "794175" @default.
- NCIT_C153479 NCIT_P330 "794175" @default.
- NCIT_C153479 NCIT_P375 "5-Aza-4'-thio-2'-deoxycytidine" @default.
- NCIT_C153479 NCIT_P399 "794175" @default.
- NCIT_C153479 normalizedInformationContent "100" @default.
- NCIT_C153479 referenceCount "1" @default.
- NCIT_C153479 hasExactSynonym "5-AZA-4'-THIO-2'-DEOXYCYTIDINE" @default.
- NCIT_C153479 hasExactSynonym "5-Aza-4'-thio-2'-deoxycytidine" @default.
- NCIT_C153479 hasExactSynonym "5-Aza-4-thio-2-deoxycytidine" @default.
- NCIT_C153479 hasExactSynonym "5-Aza-TdCyd" @default.
- NCIT_C153479 hasExactSynonym "Aza-TdC" @default.
- NCIT_C153479 hasExactSynonym "Aza-TdCyd" @default.
- NCIT_C153479 inSubset NCIT_C116977 @default.
- NCIT_C153479 inSubset NCIT_C116978 @default.
- NCIT_C153479 inSubset NCIT_C128784 @default.
- NCIT_C153479 inSubset NCIT_C157711 @default.
- NCIT_C153479 inSubset NCIT_C157712 @default.
- NCIT_C153479 inSubset NCIT_C176424 @default.
- NCIT_C153479 inSubset NCIT_C177537 @default.
- NCIT_C153479 inSubset NCIT_C63923 @default.
- NCIT_C153479 type Class @default.
- NCIT_C153479 isDefinedBy ncit.owl @default.
- NCIT_C153479 label "5-Aza-4'-thio-2'-deoxycytidine" @default.
- NCIT_C153479 subClassOf NCIT_C153479 @default.
- NCIT_C153479 subClassOf NCIT_C1557 @default.
- NCIT_C153479 subClassOf NCIT_C186664 @default.
- NCIT_C153479 subClassOf NCIT_C1908 @default.
- NCIT_C153479 subClassOf NCIT_C1909 @default.
- NCIT_C153479 subClassOf NCIT_C272 @default.
- NCIT_C153479 subClassOf NCIT_C274 @default.