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- NCIT_C1539 IAO_0000115 "A synthetic pyrimidine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, further compromising DNA replication. This agent is relatively resistant to metabolic deactivation by cytidine deaminase. RNR catalyzes the conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates necessary for DNA synthesis and is overexpressed in many tumor types." @default.
- NCIT_C1539 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1539 NCIT_NHC0 "C1539" @default.
- NCIT_C1539 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1539 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1539 NCIT_P108 "Tezacitabine" @default.
- NCIT_C1539 NCIT_P207 "C0253087" @default.
- NCIT_C1539 NCIT_P210 "171176-43-5" @default.
- NCIT_C1539 NCIT_P319 "UCC4EQS7WL" @default.
- NCIT_C1539 NCIT_P322 "FDA" @default.
- NCIT_C1539 NCIT_P322 "GDC" @default.
- NCIT_C1539 NCIT_P325 "A drug that belongs to a family of drugs called ribonucleotide reductase inhibitors." @default.
- NCIT_C1539 NCIT_P329 "354256" @default.
- NCIT_C1539 NCIT_P330 "354256" @default.
- NCIT_C1539 NCIT_P350 "C10H12FN3O4.H2O" @default.
- NCIT_C1539 NCIT_P366 "Tezacitabine" @default.
- NCIT_C1539 NCIT_P375 "Tezacitabine" @default.
- NCIT_C1539 NCIT_P399 "354256" @default.
- NCIT_C1539 normalizedInformationContent "100" @default.
- NCIT_C1539 referenceCount "1" @default.
- NCIT_C1539 hasExactSynonym "2'-Deoxy-2'-(fluoromethylene)cytidine" @default.
- NCIT_C1539 hasExactSynonym "FMdC" @default.
- NCIT_C1539 hasExactSynonym "MDL 101,731" @default.
- NCIT_C1539 hasExactSynonym "TEZACITABINE" @default.
- NCIT_C1539 hasExactSynonym "Tezacitabine" @default.
- NCIT_C1539 inSubset NCIT_C128784 @default.
- NCIT_C1539 inSubset NCIT_C157711 @default.
- NCIT_C1539 inSubset NCIT_C157712 @default.
- NCIT_C1539 inSubset NCIT_C176424 @default.
- NCIT_C1539 inSubset NCIT_C177537 @default.
- NCIT_C1539 inSubset NCIT_C63923 @default.
- NCIT_C1539 type Class @default.
- NCIT_C1539 isDefinedBy ncit.owl @default.
- NCIT_C1539 label "Tezacitabine" @default.
- NCIT_C1539 subClassOf NCIT_C1539 @default.
- NCIT_C1539 subClassOf NCIT_C1557 @default.
- NCIT_C1539 subClassOf NCIT_C186664 @default.
- NCIT_C1539 subClassOf NCIT_C1908 @default.
- NCIT_C1539 subClassOf NCIT_C1909 @default.
- NCIT_C1539 subClassOf NCIT_C2150 @default.
- NCIT_C1539 subClassOf NCIT_C272 @default.
- NCIT_C1539 subClassOf NCIT_C274 @default.
- NCIT_C1539 subClassOf NCIT_C471 @default.