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- NCIT_C1541 IAO_0000115 "A 24-base phosphorothiolate antisense oligodeoxynucleotide (ODN) for the proto-oncogene c-myb with potential antineoplastic activity. C-myb antisense oligonucleotide G4460 binds to codon sequences 2 to 9 of c-myb mRNA, inhibiting translation of the transcript. Suppression of c-myb expression with this agent may result in the restoration of normal differentiation pathways, increased antiproliferative effects, and the induction of apoptosis in early progenitor hematopoietic cells and in tumor cells that overexpress c-myb. Tumor-cell overexpression of c-myb blocks differentiation, promotes proliferation, and inhibits apoptosis." @default.
- NCIT_C1541 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1541 NCIT_NHC0 "C1541" @default.
- NCIT_C1541 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C1541 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1541 NCIT_P108 "C-myb Antisense Oligonucleotide G4460" @default.
- NCIT_C1541 NCIT_P175 "710296" @default.
- NCIT_C1541 NCIT_P207 "C0253788" @default.
- NCIT_C1541 NCIT_P322 "GDC" @default.
- NCIT_C1541 NCIT_P329 "43388" @default.
- NCIT_C1541 NCIT_P330 "43388" @default.
- NCIT_C1541 NCIT_P366 "LR-3001" @default.
- NCIT_C1541 NCIT_P375 "C-myb Antisense Oligonucleotide G4460" @default.
- NCIT_C1541 NCIT_P399 "43388" @default.
- NCIT_C1541 normalizedInformationContent "100" @default.
- NCIT_C1541 referenceCount "1" @default.
- NCIT_C1541 hasExactSynonym "C-myb Antisense Oligonucleotide G4460" @default.
- NCIT_C1541 hasExactSynonym "G4460" @default.
- NCIT_C1541 hasExactSynonym "INX-3001" @default.
- NCIT_C1541 hasExactSynonym "LR-3001" @default.
- NCIT_C1541 hasExactSynonym "OL(1)p53" @default.
- NCIT_C1541 hasExactSynonym "c-MYB Antisense Oligodeoxynucleotide" @default.
- NCIT_C1541 hasExactSynonym "c-MYB Antisense" @default.
- NCIT_C1541 hasExactSynonym "c-Myb Antisense OND" @default.
- NCIT_C1541 hasExactSynonym "c-Myb LR-3001" @default.
- NCIT_C1541 inSubset NCIT_C128784 @default.
- NCIT_C1541 inSubset NCIT_C157711 @default.
- NCIT_C1541 inSubset NCIT_C157712 @default.
- NCIT_C1541 inSubset NCIT_C176424 @default.
- NCIT_C1541 inSubset NCIT_C177537 @default.
- NCIT_C1541 type Class @default.
- NCIT_C1541 isDefinedBy ncit.owl @default.
- NCIT_C1541 label "C-myb Antisense Oligonucleotide G4460" @default.
- NCIT_C1541 subClassOf NCIT_C1291 @default.
- NCIT_C1541 subClassOf NCIT_C1541 @default.
- NCIT_C1541 subClassOf NCIT_C1908 @default.
- NCIT_C1541 subClassOf NCIT_C1909 @default.
- NCIT_C1541 subClassOf NCIT_C1962 @default.
- NCIT_C1541 subClassOf NCIT_C307 @default.