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- NCIT_C154281 IAO_0000115 "A preparation of genetically modified autologous central memory (Tcm) enriched T-cells transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-human epidermal growth factor receptor 2 (HER2) single chain variable fragment (scFv) derived from trastuzumab, with a 4-1BB (CD137) costimulatory domain that is linked to the signaling domain of the T-cell antigen receptor complex zeta chain (CD3-zeta) (BBz), and truncated CD19 (CD19t), with potential immunostimulatory and antineoplastic activities. Upon intravenous infusion, Anti-HER2-CAR-4-1BB-CD19t+-expressing Tcm-enriched T-lymphocytes are directed against HER2-expressing cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase, is mutated or overexpressed in many tumor cell types, plays a significant role in tumor cell proliferation and tumor vascularization. The BBz costimulatory signaling domain enhances proliferation of T-cells and antitumor activity, while CD19t, a marker for transduction, is utilized to calculate CAR T-cell dosing and for CAR-expressing cell tracking. Tcm cells have the capacity for long-lived persistence and retain their ability to proliferate upon antigen re-encounter. The immunoglobulin G4 (IgG4) extracellular spacer contains a double mutation, (L235E;N297Q) (EQ) within the CH2 region to reduce Fc receptor recognition." @default.
- NCIT_C154281 NCIT_NHC0 "C154281" @default.
- NCIT_C154281 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C154281 NCIT_P108 "Autologous Anti-HER2-CAR-4-1BB-CD3zeta-CD19t+-expressing Tcm-enriched T-lymphocytes" @default.
- NCIT_C154281 NCIT_P208 "CL555282" @default.
- NCIT_C154281 NCIT_P329 "794190" @default.
- NCIT_C154281 NCIT_P330 "794190" @default.
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- NCIT_C154281 hasExactSynonym "Autologous Anti-HER2-CAR-4-1BB-CD3zeta-CD19t+-expressing Tcm-enriched T-lymphocytes" @default.
- NCIT_C154281 hasExactSynonym "Autologous HER2(EQ) BBz/CD19t+ Tcm Cells" @default.
- NCIT_C154281 hasExactSynonym "Autologous Memory Enriched HER2(EQ)BBzeta/CD19t+-expressing T-cells" @default.
- NCIT_C154281 inSubset NCIT_C128784 @default.
- NCIT_C154281 inSubset NCIT_C176424 @default.
- NCIT_C154281 type Class @default.
- NCIT_C154281 isDefinedBy ncit.owl @default.
- NCIT_C154281 label "Autologous Anti-HER2-CAR-4-1BB-CD3zeta-CD19t+-expressing Tcm-enriched T-lymphocytes" @default.
- NCIT_C154281 subClassOf NCIT_C129820 @default.
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- NCIT_C154281 subClassOf NCIT_C307 @default.
- NCIT_C154281 subClassOf NCIT_C308 @default.