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- NCIT_C154287 IAO_0000115 "An orally available inhibitor of the specific KRAS mutation, p.G12C, with potential antineoplastic activity. Upon oral administration, sotorasib selectively targets, binds to and inhibits the activity of the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells. The KRAS p.G12C mutation is seen in some tumor cell types and plays a key role in tumor cell proliferation." @default.
- NCIT_C154287 NCIT_A32 NCIT_C1909 @default.
- NCIT_C154287 NCIT_A7 NCIT_C98365 @default.
- NCIT_C154287 NCIT_NHC0 "C154287" @default.
- NCIT_C154287 NCIT_P106 "Organic Chemical" @default.
- NCIT_C154287 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C154287 NCIT_P107 "Sotorasib" @default.
- NCIT_C154287 NCIT_P108 "Sotorasib" @default.
- NCIT_C154287 NCIT_P208 "CL555284" @default.
- NCIT_C154287 NCIT_P210 "2296729-00-3" @default.
- NCIT_C154287 NCIT_P302 "adult patients with KRAS G12C mutated locally advanced or metastatic non-small cell lung cancer (NSCLC)" @default.
- NCIT_C154287 NCIT_P319 "2B2VM6UC8G" @default.
- NCIT_C154287 NCIT_P322 "CTRP" @default.
- NCIT_C154287 NCIT_P322 "FDA" @default.
- NCIT_C154287 NCIT_P322 "GDC" @default.
- NCIT_C154287 NCIT_P329 "794411" @default.
- NCIT_C154287 NCIT_P330 "794411" @default.
- NCIT_C154287 NCIT_P375 "KRAS Mutant-targeting AMG 510" @default.
- NCIT_C154287 NCIT_P375 "Sotorasib" @default.
- NCIT_C154287 NCIT_P399 "794411" @default.
- NCIT_C154287 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C154287 referenceCount "2" @default.
- NCIT_C154287 hasExactSynonym "AMG 510" @default.
- NCIT_C154287 hasExactSynonym "AMG-510" @default.
- NCIT_C154287 hasExactSynonym "AMG510" @default.
- NCIT_C154287 hasExactSynonym "Lumakras" @default.
- NCIT_C154287 hasExactSynonym "Lumykras" @default.
- NCIT_C154287 hasExactSynonym "SOTORASIB" @default.
- NCIT_C154287 hasExactSynonym "Sotorasib" @default.
- NCIT_C154287 inSubset NCIT_C116977 @default.
- NCIT_C154287 inSubset NCIT_C116978 @default.
- NCIT_C154287 inSubset NCIT_C128784 @default.
- NCIT_C154287 inSubset NCIT_C157711 @default.
- NCIT_C154287 inSubset NCIT_C157712 @default.
- NCIT_C154287 inSubset NCIT_C176424 @default.
- NCIT_C154287 inSubset NCIT_C177537 @default.
- NCIT_C154287 inSubset NCIT_C63923 @default.
- NCIT_C154287 type Class @default.
- NCIT_C154287 isDefinedBy ncit.owl @default.
- NCIT_C154287 label "Sotorasib" @default.
- NCIT_C154287 subClassOf NCIT_C154287 @default.
- NCIT_C154287 subClassOf NCIT_C163758 @default.
- NCIT_C154287 subClassOf NCIT_C1902 @default.
- NCIT_C154287 subClassOf NCIT_C1908 @default.
- NCIT_C154287 subClassOf NCIT_C1909 @default.
- NCIT_C154287 subClassOf NCIT_C200729 @default.
- NCIT_C154287 subClassOf NCIT_C2189 @default.
- NCIT_C154287 subClassOf NCIT_C274 @default.