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- NCIT_C154328 IAO_0000115 "An orally available, reversible, noncompetitive inhibitor of lysine-specific demethylase 1 (LSD1, or KDM1A), with potential antineoplastic activity. Upon oral administration, seclidemstat reversibly inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone 3 (H3K4) to mono- and unmethylated H3K4, respectively. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes." @default.
- NCIT_C154328 NCIT_A32 NCIT_C1909 @default.
- NCIT_C154328 NCIT_A7 NCIT_C78143 @default.
- NCIT_C154328 NCIT_NHC0 "C154328" @default.
- NCIT_C154328 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C154328 NCIT_P107 "Seclidemstat" @default.
- NCIT_C154328 NCIT_P108 "Seclidemstat" @default.
- NCIT_C154328 NCIT_P208 "CL555222" @default.
- NCIT_C154328 NCIT_P210 "1423715-37-0" @default.
- NCIT_C154328 NCIT_P319 "TYH386V3WJ" @default.
- NCIT_C154328 NCIT_P322 "CTRP" @default.
- NCIT_C154328 NCIT_P322 "FDA" @default.
- NCIT_C154328 NCIT_P322 "GDC" @default.
- NCIT_C154328 NCIT_P329 "794410" @default.
- NCIT_C154328 NCIT_P330 "794410" @default.
- NCIT_C154328 NCIT_P375 "Seclidemstat" @default.
- NCIT_C154328 NCIT_P399 "794410" @default.
- NCIT_C154328 normalizedInformationContent "100" @default.
- NCIT_C154328 referenceCount "1" @default.
- NCIT_C154328 hasExactSynonym "LSD1 Inhibitor SP-2577" @default.
- NCIT_C154328 hasExactSynonym "SECLIDEMSTAT" @default.
- NCIT_C154328 hasExactSynonym "SP 2577" @default.
- NCIT_C154328 hasExactSynonym "SP-2577" @default.
- NCIT_C154328 hasExactSynonym "SP2577" @default.
- NCIT_C154328 hasExactSynonym "Seclidemstat" @default.
- NCIT_C154328 inSubset NCIT_C116977 @default.
- NCIT_C154328 inSubset NCIT_C116978 @default.
- NCIT_C154328 inSubset NCIT_C128784 @default.
- NCIT_C154328 inSubset NCIT_C157711 @default.
- NCIT_C154328 inSubset NCIT_C157712 @default.
- NCIT_C154328 inSubset NCIT_C176424 @default.
- NCIT_C154328 inSubset NCIT_C177537 @default.
- NCIT_C154328 inSubset NCIT_C63923 @default.
- NCIT_C154328 type Class @default.
- NCIT_C154328 isDefinedBy ncit.owl @default.
- NCIT_C154328 label "Seclidemstat" @default.
- NCIT_C154328 subClassOf NCIT_C129824 @default.
- NCIT_C154328 subClassOf NCIT_C129825 @default.
- NCIT_C154328 subClassOf NCIT_C154328 @default.
- NCIT_C154328 subClassOf NCIT_C1908 @default.
- NCIT_C154328 subClassOf NCIT_C1909 @default.
- NCIT_C154328 subClassOf NCIT_C2189 @default.
- NCIT_C154328 subClassOf NCIT_C274 @default.
- NCIT_C154328 subClassOf NCIT_C471 @default.