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- NCIT_C154440 IAO_0000115 "The monohydrate form of bosutinib, a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid tumors. Abl kinase is upregulated in the presence of the abnormal Bcr-abl fusion protein which is commonly associated with chronic myeloid leukemia (CML). Overexpression of specific Src kinases is also associated with the imatinib-resistant CML phenotype." @default.
- NCIT_C154440 NCIT_A32 NCIT_C1909 @default.
- NCIT_C154440 NCIT_A7 NCIT_C17270 @default.
- NCIT_C154440 NCIT_NHC0 "C154440" @default.
- NCIT_C154440 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C154440 NCIT_P107 "Bosutinib Monohydrate" @default.
- NCIT_C154440 NCIT_P108 "Bosutinib Monohydrate" @default.
- NCIT_C154440 NCIT_P208 "CL555365" @default.
- NCIT_C154440 NCIT_P210 "918639-08-4" @default.
- NCIT_C154440 NCIT_P319 "844ZJE6I55" @default.
- NCIT_C154440 NCIT_P322 "CTRP" @default.
- NCIT_C154440 NCIT_P322 "FDA" @default.
- NCIT_C154440 NCIT_P322 "GDC" @default.
- NCIT_C154440 NCIT_P375 "Bosutinib Monohydrate" @default.
- NCIT_C154440 NCIT_R124 NCIT_C17828 @default.
- NCIT_C154440 NCIT_R124 NCIT_C18992 @default.
- NCIT_C154440 NCIT_R124 NCIT_C19143 @default.
- NCIT_C154440 NCIT_R124 NCIT_C21124 @default.
- NCIT_C154440 NCIT_R124 NCIT_C40702 @default.
- NCIT_C154440 NCIT_R124 NCIT_C40703 @default.
- NCIT_C154440 NCIT_R124 NCIT_C40704 @default.
- NCIT_C154440 NCIT_R125 NCIT_C17133 @default.
- NCIT_C154440 NCIT_R125 NCIT_C17828 @default.
- NCIT_C154440 NCIT_R125 NCIT_C18081 @default.
- NCIT_C154440 NCIT_R125 NCIT_C20480 @default.
- NCIT_C154440 NCIT_R125 NCIT_C20751 @default.
- NCIT_C154440 NCIT_R125 NCIT_C40821 @default.
- NCIT_C154440 normalizedInformationContent "100" @default.
- NCIT_C154440 referenceCount "1" @default.
- NCIT_C154440 hasExactSynonym "3-Quinolinecarbonitrile, 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-, Hydrate (1:1)" @default.
- NCIT_C154440 hasExactSynonym "BOSUTINIB MONOHYDRATE" @default.
- NCIT_C154440 hasExactSynonym "Bosulif" @default.
- NCIT_C154440 hasExactSynonym "Bosutinib Monohydrate" @default.
- NCIT_C154440 hasExactSynonym "SKI-606 Monohydrate" @default.
- NCIT_C154440 inSubset NCIT_C116977 @default.
- NCIT_C154440 inSubset NCIT_C116978 @default.
- NCIT_C154440 inSubset NCIT_C128784 @default.
- NCIT_C154440 inSubset NCIT_C157711 @default.
- NCIT_C154440 inSubset NCIT_C157712 @default.
- NCIT_C154440 inSubset NCIT_C177537 @default.
- NCIT_C154440 inSubset NCIT_C63923 @default.
- NCIT_C154440 type Class @default.
- NCIT_C154440 isDefinedBy ncit.owl @default.
- NCIT_C154440 label "Bosutinib Monohydrate" @default.
- NCIT_C154440 subClassOf NCIT_C129824 @default.
- NCIT_C154440 subClassOf NCIT_C129825 @default.
- NCIT_C154440 subClassOf NCIT_C1404 @default.
- NCIT_C154440 subClassOf NCIT_C154440 @default.
- NCIT_C154440 subClassOf NCIT_C155700 @default.
- NCIT_C154440 subClassOf NCIT_C163758 @default.
- NCIT_C154440 subClassOf NCIT_C1908 @default.
- NCIT_C154440 subClassOf NCIT_C1909 @default.
- NCIT_C154440 subClassOf NCIT_C1967 @default.
- NCIT_C154440 subClassOf NCIT_C2189 @default.
- NCIT_C154440 subClassOf NCIT_C274 @default.
- NCIT_C154440 subClassOf NCIT_C471 @default.