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- NCIT_C1545 IAO_0000115 "A recombinant agent that is chemically identical or similar to the endogenous form of the human cytokine interleukin-15 (IL-15) with immunomodulating activity. IL-15, secreted by mononuclear phagocytes (and some other cell types) following viral infection, regulates T and natural killer cell activation and proliferation. This cytokine induces activation of transcription activators STAT3, STAT5, and STAT6 via JAK kinase signal transduction pathways in mast cells, T cells, and dendritic epidermal T cells. IL-15 and interleukin-2 (IL-2) are structurally similar and share many biological activities; both may bind to common hematopoietin receptor subunits, negatively regulating each other's activity. CD8+ memory T cell number has been shown to be regulated by a balance between IL-15 and IL-2." @default.
- NCIT_C1545 NCIT_NHC0 "C1545" @default.
- NCIT_C1545 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1545 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1545 NCIT_P107 "Recombinant Human Interleukin-15" @default.
- NCIT_C1545 NCIT_P108 "Recombinant Human Interleukin-15" @default.
- NCIT_C1545 NCIT_P207 "C1522569" @default.
- NCIT_C1545 NCIT_P319 "VL2UPV1APW" @default.
- NCIT_C1545 NCIT_P322 "CTRP" @default.
- NCIT_C1545 NCIT_P322 "FDA" @default.
- NCIT_C1545 NCIT_P329 "661035" @default.
- NCIT_C1545 NCIT_P330 "661035" @default.
- NCIT_C1545 NCIT_P366 "Therapeutic_Interleukin-15" @default.
- NCIT_C1545 NCIT_P399 "661035" @default.
- NCIT_C1545 NCIT_R125 NCIT_C17828 @default.
- NCIT_C1545 NCIT_R125 NCIT_C18081 @default.
- NCIT_C1545 NCIT_R125 NCIT_C20480 @default.
- NCIT_C1545 NCIT_R125 NCIT_C20751 @default.
- NCIT_C1545 normalizedInformationContent "100" @default.
- NCIT_C1545 referenceCount "1" @default.
- NCIT_C1545 hasExactSynonym "IL15" @default.
- NCIT_C1545 hasExactSynonym "Interleukin 15" @default.
- NCIT_C1545 hasExactSynonym "RECOMBINANT HUMAN INTERLEUKIN-15" @default.
- NCIT_C1545 hasExactSynonym "Recombinant Human Interleukin-15" @default.
- NCIT_C1545 hasExactSynonym "rIL15" @default.
- NCIT_C1545 hasExactSynonym "rhIL-15" @default.
- NCIT_C1545 inSubset NCIT_C116977 @default.
- NCIT_C1545 inSubset NCIT_C116978 @default.
- NCIT_C1545 inSubset NCIT_C176424 @default.
- NCIT_C1545 inSubset NCIT_C63923 @default.
- NCIT_C1545 type Class @default.
- NCIT_C1545 isDefinedBy ncit.owl @default.
- NCIT_C1545 label "Recombinant Human Interleukin-15" @default.
- NCIT_C1545 subClassOf NCIT_C1283 @default.
- NCIT_C1545 subClassOf NCIT_C1545 @default.
- NCIT_C1545 subClassOf NCIT_C1908 @default.
- NCIT_C1545 subClassOf NCIT_C1909 @default.
- NCIT_C1545 subClassOf NCIT_C307 @default.
- NCIT_C1545 subClassOf NCIT_C308 @default.
- NCIT_C1545 subClassOf NCIT_C593 @default.