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- NCIT_C154552 IAO_0000115 "A recombinant, humanized monoclonal antibody directed against the vascular endothelial growth factor receptor 2 (VEGFR-2), with potential anti-angiogenic and antineoplastic activities. Upon intravenous injection, gentuximab specifically binds to VEGFR-2, preventing the binding of its ligand, vascular endothelial growth factor (VEGF). Inhibition of VEGFR-2 signaling may potentially inhibit tumor angiogenesis and decrease nutrient supply to tumor cells, resulting in tumor cell death. VEGFR-2 is a type V receptor tyrosine kinase (RTK) expressed on endothelial cells and some tumor cells that regulates endothelial migration and proliferation." @default.
- NCIT_C154552 NCIT_A32 NCIT_C1909 @default.
- NCIT_C154552 NCIT_NHC0 "C154552" @default.
- NCIT_C154552 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C154552 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C154552 NCIT_P108 "Gentuximab" @default.
- NCIT_C154552 NCIT_P208 "CL555348" @default.
- NCIT_C154552 NCIT_P322 "GDC" @default.
- NCIT_C154552 NCIT_P329 "794351" @default.
- NCIT_C154552 NCIT_P330 "794351" @default.
- NCIT_C154552 NCIT_P375 "Gentuximab" @default.
- NCIT_C154552 NCIT_P399 "794351" @default.
- NCIT_C154552 NCIT_R124 NCIT_C17710 @default.
- NCIT_C154552 NCIT_R124 NCIT_C17828 @default.
- NCIT_C154552 NCIT_R124 NCIT_C18219 @default.
- NCIT_C154552 NCIT_R124 NCIT_C19986 @default.
- NCIT_C154552 NCIT_R124 NCIT_C40474 @default.
- NCIT_C154552 normalizedInformationContent "100" @default.
- NCIT_C154552 referenceCount "1" @default.
- NCIT_C154552 hasExactSynonym "Gentuximab" @default.
- NCIT_C154552 inSubset NCIT_C128784 @default.
- NCIT_C154552 inSubset NCIT_C157711 @default.
- NCIT_C154552 inSubset NCIT_C157712 @default.
- NCIT_C154552 inSubset NCIT_C176424 @default.
- NCIT_C154552 inSubset NCIT_C177537 @default.
- NCIT_C154552 type Class @default.
- NCIT_C154552 isDefinedBy ncit.owl @default.
- NCIT_C154552 label "Gentuximab" @default.
- NCIT_C154552 subClassOf NCIT_C129821 @default.
- NCIT_C154552 subClassOf NCIT_C129822 @default.
- NCIT_C154552 subClassOf NCIT_C154552 @default.
- NCIT_C154552 subClassOf NCIT_C163758 @default.
- NCIT_C154552 subClassOf NCIT_C163953 @default.
- NCIT_C154552 subClassOf NCIT_C1742 @default.
- NCIT_C154552 subClassOf NCIT_C1908 @default.
- NCIT_C154552 subClassOf NCIT_C1909 @default.
- NCIT_C154552 subClassOf NCIT_C20401 @default.
- NCIT_C154552 subClassOf NCIT_C274 @default.
- NCIT_C154552 subClassOf NCIT_C307 @default.
- NCIT_C154552 subClassOf NCIT_C308 @default.
- NCIT_C154552 subClassOf NCIT_C93170 @default.