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- NCIT_C154560 IAO_0000115 "An orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, NOV1401 selectively binds to PARP-1 and -2, thereby preventing PARP-1 and -2-mediated DNA repair. This promotes genetic instability and enhances the accumulation of single and double strand DNA breaks, ultimately leading to apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks." @default.
- NCIT_C154560 NCIT_A32 NCIT_C1909 @default.
- NCIT_C154560 NCIT_NHC0 "C154560" @default.
- NCIT_C154560 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C154560 NCIT_P108 "PARP 1/2 Inhibitor NOV1401" @default.
- NCIT_C154560 NCIT_P208 "CL555354" @default.
- NCIT_C154560 NCIT_P322 "GDC" @default.
- NCIT_C154560 NCIT_P329 "794354" @default.
- NCIT_C154560 NCIT_P330 "794354" @default.
- NCIT_C154560 NCIT_P375 "PARP 1/2 Inhibitor NOV1401" @default.
- NCIT_C154560 NCIT_P399 "794354" @default.
- NCIT_C154560 NCIT_R146 NCIT_C104101 @default.
- NCIT_C154560 NCIT_R146 NCIT_C16554 @default.
- NCIT_C154560 NCIT_R146 NCIT_C17021 @default.
- NCIT_C154560 NCIT_R146 NCIT_C17210 @default.
- NCIT_C154560 NCIT_R146 NCIT_C17434 @default.
- NCIT_C154560 NCIT_R146 NCIT_C20027 @default.
- NCIT_C154560 NCIT_R146 NCIT_C21170 @default.
- NCIT_C154560 NCIT_R146 NCIT_C26548 @default.
- NCIT_C154560 NCIT_R146 NCIT_C48215 @default.
- NCIT_C154560 normalizedInformationContent "100" @default.
- NCIT_C154560 referenceCount "1" @default.
- NCIT_C154560 hasExactSynonym "PARP 1/2 Inhibitor NOV1401" @default.
- NCIT_C154560 inSubset NCIT_C128784 @default.
- NCIT_C154560 inSubset NCIT_C157711 @default.
- NCIT_C154560 inSubset NCIT_C157712 @default.
- NCIT_C154560 inSubset NCIT_C176424 @default.
- NCIT_C154560 inSubset NCIT_C177537 @default.
- NCIT_C154560 type Class @default.
- NCIT_C154560 isDefinedBy ncit.owl @default.
- NCIT_C154560 label "PARP 1/2 Inhibitor NOV1401" @default.
- NCIT_C154560 subClassOf NCIT_C154560 @default.
- NCIT_C154560 subClassOf NCIT_C163758 @default.
- NCIT_C154560 subClassOf NCIT_C1908 @default.
- NCIT_C154560 subClassOf NCIT_C1909 @default.
- NCIT_C154560 subClassOf NCIT_C274 @default.
- NCIT_C154560 subClassOf NCIT_C471 @default.
- NCIT_C154560 subClassOf NCIT_C62554 @default.