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- NCIT_C154563 IAO_0000115 "A vaccine composed of a peptide derived from the immune checkpoint molecule programmed death ligand 2 (PD-L2) combined with the immunoadjuvant montanide ISA-51, with potential immunomodulating and antineoplastic activities. Vaccination with PD-L2 peptide-montanide vaccine may mount an immune response against PD-L2 expressing cells. This may enhance T-cell proliferation, cytokine production, and T-cell mediated cytolysis. PD-L2 binding to its cognate receptor, programmed cell death protein 1 (PD-1; PDCD1; CD279), downregulates T-cell responses and enhances immune evasion. Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens." @default.
- NCIT_C154563 NCIT_NHC0 "C154563" @default.
- NCIT_C154563 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C154563 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C154563 NCIT_P108 "PD-L2 Peptide-Montanide Vaccine" @default.
- NCIT_C154563 NCIT_P208 "CL555359" @default.
- NCIT_C154563 NCIT_P329 "794356" @default.
- NCIT_C154563 NCIT_P330 "794356" @default.
- NCIT_C154563 NCIT_P399 "794356" @default.
- NCIT_C154563 NCIT_R124 NCIT_C17828 @default.
- NCIT_C154563 NCIT_R124 NCIT_C17930 @default.
- NCIT_C154563 NCIT_R124 NCIT_C17937 @default.
- NCIT_C154563 NCIT_R124 NCIT_C18839 @default.
- NCIT_C154563 NCIT_R124 NCIT_C21124 @default.
- NCIT_C154563 NCIT_R124 NCIT_C45548 @default.
- NCIT_C154563 normalizedInformationContent "100" @default.
- NCIT_C154563 referenceCount "1" @default.
- NCIT_C154563 hasExactSynonym "PD-L2 Peptide Plus Montanide ISA-51 Vaccine" @default.
- NCIT_C154563 hasExactSynonym "PD-L2 Peptide Plus Montanide Vaccine" @default.
- NCIT_C154563 hasExactSynonym "PD-L2 Peptide-Montanide Vaccine" @default.
- NCIT_C154563 hasExactSynonym "Programmed Death Ligand 2 Peptide Vaccine" @default.
- NCIT_C154563 inSubset NCIT_C128784 @default.
- NCIT_C154563 inSubset NCIT_C176424 @default.
- NCIT_C154563 type Class @default.
- NCIT_C154563 isDefinedBy ncit.owl @default.
- NCIT_C154563 label "PD-L2 Peptide-Montanide Vaccine" @default.
- NCIT_C154563 subClassOf NCIT_C129820 @default.
- NCIT_C154563 subClassOf NCIT_C154563 @default.
- NCIT_C154563 subClassOf NCIT_C1663 @default.
- NCIT_C154563 subClassOf NCIT_C1752 @default.
- NCIT_C154563 subClassOf NCIT_C1908 @default.
- NCIT_C154563 subClassOf NCIT_C1909 @default.
- NCIT_C154563 subClassOf NCIT_C274 @default.
- NCIT_C154563 subClassOf NCIT_C307 @default.
- NCIT_C154563 subClassOf NCIT_C308 @default.
- NCIT_C154563 subClassOf NCIT_C923 @default.