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- NCIT_C154564 IAO_0000115 "A vaccine composed of peptides derived from the immune checkpoint molecules, programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2), combined with the immunoadjuvant montanide ISA-51, with potential immunomodulating and antineoplastic activities. Vaccination with PD-L1/PD-L2 peptide-montanide vaccine may stimulate an immune response against PD-L1 and PD-L2 expressing cells. This may enhance T-cell proliferation, cytokine production, and T-cell mediated cytolysis. Binding of programmed cell death protein 1 (PD-1; PDCD1; CD279) by its ligands, PD-L1 and PD-L2, results in downregulation of T-cell responses and enhanced immune evasion. Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens." @default.
- NCIT_C154564 NCIT_NHC0 "C154564" @default.
- NCIT_C154564 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C154564 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C154564 NCIT_P108 "PD-L1/PD-L2 Peptide-Montanide Vaccine" @default.
- NCIT_C154564 NCIT_P208 "CL555360" @default.
- NCIT_C154564 NCIT_P329 "794357" @default.
- NCIT_C154564 NCIT_P330 "794357" @default.
- NCIT_C154564 NCIT_P399 "794357" @default.
- NCIT_C154564 NCIT_R124 NCIT_C17828 @default.
- NCIT_C154564 NCIT_R124 NCIT_C17930 @default.
- NCIT_C154564 NCIT_R124 NCIT_C17937 @default.
- NCIT_C154564 NCIT_R124 NCIT_C18839 @default.
- NCIT_C154564 NCIT_R124 NCIT_C21124 @default.
- NCIT_C154564 NCIT_R124 NCIT_C45548 @default.
- NCIT_C154564 normalizedInformationContent "100" @default.
- NCIT_C154564 referenceCount "1" @default.
- NCIT_C154564 hasExactSynonym "PD-L1/PD-L2 Peptide Plus Montanide ISA-51 Vaccine" @default.
- NCIT_C154564 hasExactSynonym "PD-L1/PD-L2 Peptide Plus Montanide Vaccine" @default.
- NCIT_C154564 hasExactSynonym "PD-L1/PD-L2 Peptide-Montanide Vaccine" @default.
- NCIT_C154564 inSubset NCIT_C128784 @default.
- NCIT_C154564 inSubset NCIT_C176424 @default.
- NCIT_C154564 type Class @default.
- NCIT_C154564 isDefinedBy ncit.owl @default.
- NCIT_C154564 label "PD-L1/PD-L2 Peptide-Montanide Vaccine" @default.
- NCIT_C154564 subClassOf NCIT_C129820 @default.
- NCIT_C154564 subClassOf NCIT_C154564 @default.
- NCIT_C154564 subClassOf NCIT_C1663 @default.
- NCIT_C154564 subClassOf NCIT_C1752 @default.
- NCIT_C154564 subClassOf NCIT_C1908 @default.
- NCIT_C154564 subClassOf NCIT_C1909 @default.
- NCIT_C154564 subClassOf NCIT_C274 @default.
- NCIT_C154564 subClassOf NCIT_C307 @default.
- NCIT_C154564 subClassOf NCIT_C308 @default.
- NCIT_C154564 subClassOf NCIT_C923 @default.