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- NCIT_C154570 IAO_0000115 "The esylate salt form of nintedanib, an orally bioavailable, indolinone-derived inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs), with potential antiangiogenic, antifibrotic and antineoplastic activities. Upon administration, nintedanib selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and colony stimulating factor 1 receptor (CSF1R) tyrosine kinases, which may result in the induction of endothelial cell apoptosis, the reduction in tumor vasculature, the inhibition of tumor cell proliferation and migration, and antifibrotic activity in pulmonary fibrosis. In addition, nintedanib also binds to and inhibits members of the Src family of tyrosine kinases, including Src, Lck and Lyn, and fms-like tyrosine kinase 3 (FLT-3). VEGFR, FGFR, PDGFR and CSF1R RTKs play key roles in tumor angiogenesis, tumor cell proliferation and metastasis, as well as pulmonary fibrosis." @default.
- NCIT_C154570 NCIT_A6 NCIT_C62765 @default.
- NCIT_C154570 NCIT_NHC0 "C154570" @default.
- NCIT_C154570 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C154570 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C154570 NCIT_P108 "Nintedanib Esylate" @default.
- NCIT_C154570 NCIT_P208 "CL555362" @default.
- NCIT_C154570 NCIT_P210 "656247-18-6" @default.
- NCIT_C154570 NCIT_P319 "42F62RTZ4G" @default.
- NCIT_C154570 NCIT_P322 "FDA" @default.
- NCIT_C154570 normalizedInformationContent "100" @default.
- NCIT_C154570 referenceCount "1" @default.
- NCIT_C154570 hasExactSynonym "Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate Ethanesulfonate" @default.
- NCIT_C154570 hasExactSynonym "NINTEDANIB ESYLATE" @default.
- NCIT_C154570 hasExactSynonym "Nintedanib Esylate" @default.
- NCIT_C154570 hasExactSynonym "Nintedanib Ethanesulfonate" @default.
- NCIT_C154570 hasExactSynonym "Ofev" @default.
- NCIT_C154570 inSubset NCIT_C173381 @default.
- NCIT_C154570 inSubset NCIT_C173383 @default.
- NCIT_C154570 inSubset NCIT_C63923 @default.
- NCIT_C154570 type Class @default.
- NCIT_C154570 isDefinedBy ncit.owl @default.
- NCIT_C154570 label "Nintedanib Esylate" @default.
- NCIT_C154570 subClassOf NCIT_C129824 @default.
- NCIT_C154570 subClassOf NCIT_C129825 @default.
- NCIT_C154570 subClassOf NCIT_C1404 @default.
- NCIT_C154570 subClassOf NCIT_C154570 @default.
- NCIT_C154570 subClassOf NCIT_C155727 @default.
- NCIT_C154570 subClassOf NCIT_C163758 @default.
- NCIT_C154570 subClassOf NCIT_C164035 @default.
- NCIT_C154570 subClassOf NCIT_C1742 @default.
- NCIT_C154570 subClassOf NCIT_C1908 @default.
- NCIT_C154570 subClassOf NCIT_C1909 @default.
- NCIT_C154570 subClassOf NCIT_C1967 @default.
- NCIT_C154570 subClassOf NCIT_C2189 @default.
- NCIT_C154570 subClassOf NCIT_C274 @default.
- NCIT_C154570 subClassOf NCIT_C471 @default.