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- NCIT_C1546 IAO_0000115 "The cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity of the cryptophycins has been associated with their destabilization of microtubules and induction of bcl-2 phosphorylation leading to apoptosis. Cryptophycins demonstrated activity against the wide spectrum of solid tumors including those that overexpress the multidrug resistance efflux pump P-glycoprotein. (NCI)" @default.
- NCIT_C1546 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1546 NCIT_NHC0 "C1546" @default.
- NCIT_C1546 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1546 NCIT_P106 "Antibiotic" @default.
- NCIT_C1546 NCIT_P108 "Cryptophycin" @default.
- NCIT_C1546 NCIT_P175 "667642" @default.
- NCIT_C1546 NCIT_P207 "C0257217" @default.
- NCIT_C1546 NCIT_P210 "124689-65-2" @default.
- NCIT_C1546 NCIT_P319 "XO974V2M5T" @default.
- NCIT_C1546 NCIT_P322 "FDA" @default.
- NCIT_C1546 NCIT_P322 "GDC" @default.
- NCIT_C1546 NCIT_P366 "Cryptophycin" @default.
- NCIT_C1546 NCIT_P375 "Cryptophycin" @default.
- NCIT_C1546 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1546 NCIT_R124 NCIT_C20480 @default.
- NCIT_C1546 NCIT_R124 NCIT_C40795 @default.
- NCIT_C1546 NCIT_R124 NCIT_C40798 @default.
- NCIT_C1546 normalizedInformationContent "100" @default.
- NCIT_C1546 referenceCount "1" @default.
- NCIT_C1546 hasExactSynonym "10-((3-Chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone" @default.
- NCIT_C1546 hasExactSynonym "CRYPTOPHYCIN 1" @default.
- NCIT_C1546 hasExactSynonym "Cryptophycin 1" @default.
- NCIT_C1546 hasExactSynonym "Cryptophycin" @default.
- NCIT_C1546 inSubset NCIT_C128784 @default.
- NCIT_C1546 inSubset NCIT_C157711 @default.
- NCIT_C1546 inSubset NCIT_C157712 @default.
- NCIT_C1546 inSubset NCIT_C177537 @default.
- NCIT_C1546 inSubset NCIT_C63923 @default.
- NCIT_C1546 type Class @default.
- NCIT_C1546 isDefinedBy ncit.owl @default.
- NCIT_C1546 label "Cryptophycin" @default.
- NCIT_C1546 subClassOf NCIT_C1546 @default.
- NCIT_C1546 subClassOf NCIT_C186664 @default.
- NCIT_C1546 subClassOf NCIT_C1908 @default.
- NCIT_C1546 subClassOf NCIT_C1909 @default.
- NCIT_C1546 subClassOf NCIT_C25974 @default.
- NCIT_C1546 subClassOf NCIT_C273 @default.
- NCIT_C1546 subClassOf NCIT_C274 @default.
- NCIT_C1546 subClassOf NCIT_C67422 @default.