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- NCIT_C1549 IAO_0000115 "A single-chain immunotoxin consisting of Fv fragments of the BR96 monoclonal antibody (MoAb) and a truncated Pseudomonas exotoxin (PE40) that lacking the binding domain. MoAb BR96 specifically binds to Lewis Y-related carbohydrate antigen, a cell surface antigen overexpressed in many carcinomas. After internalization, PE40 causes ADP-ribosylation of transcription elongation factor 2, thereby inactivating elongation factor 2 and inhibiting protein synthesis in the cancer cells." @default.
- NCIT_C1549 NCIT_NHC0 "C1549" @default.
- NCIT_C1549 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1549 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1549 NCIT_P108 "BR96 sFv-PE40" @default.
- NCIT_C1549 NCIT_P207 "C0259637" @default.
- NCIT_C1549 NCIT_P366 "BR96_sFv-PE40" @default.
- NCIT_C1549 normalizedInformationContent "100" @default.
- NCIT_C1549 referenceCount "1" @default.
- NCIT_C1549 hasExactSynonym "BR96 sFv-PE40" @default.
- NCIT_C1549 hasExactSynonym "SGN-10" @default.
- NCIT_C1549 type Class @default.
- NCIT_C1549 isDefinedBy ncit.owl @default.
- NCIT_C1549 label "BR96 sFv-PE40" @default.
- NCIT_C1549 subClassOf NCIT_C1512 @default.
- NCIT_C1549 subClassOf NCIT_C1549 @default.
- NCIT_C1549 subClassOf NCIT_C1908 @default.
- NCIT_C1549 subClassOf NCIT_C1909 @default.
- NCIT_C1549 subClassOf NCIT_C307 @default.
- NCIT_C1549 subClassOf NCIT_C308 @default.
- NCIT_C1549 subClassOf NCIT_C575 @default.
- NCIT_C1549 subClassOf NCIT_C78532 @default.