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- NCIT_C155292 IAO_0000115 "A radiotracer consisting of a 1(2H)phthalazinone-based poly(ADP-ribose) polymerase 1 (PARP1) inhibitor (PARPi) radiolabeled with the positron emitting isotope fluorine F 18, which can potentially be used for the imaging of PARP1 expression using positron emission tomography (PET). Upon administration, fluorine F 18 PARPi targets and binds to PARP1. Upon PET, PARP1-expressing tumor cells can be visualized. PARP1, which is overexpressed in many cancer cell types, catalyzes post-translational ADP-ribosylation of nuclear proteins and plays a key role in the repair of DNA strand breaks." @default.
- NCIT_C155292 NCIT_A7 NCIT_C48215 @default.
- NCIT_C155292 NCIT_NHC0 "C155292" @default.
- NCIT_C155292 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C155292 NCIT_P107 "Fluorine F 18 PARP Inhibitor" @default.
- NCIT_C155292 NCIT_P108 "Fluorine F 18 PARP Inhibitor" @default.
- NCIT_C155292 NCIT_P208 "CL555925" @default.
- NCIT_C155292 NCIT_P322 "CTRP" @default.
- NCIT_C155292 NCIT_P329 "794783" @default.
- NCIT_C155292 NCIT_P330 "794783" @default.
- NCIT_C155292 NCIT_P399 "794783" @default.
- NCIT_C155292 normalizedInformationContent "100" @default.
- NCIT_C155292 referenceCount "1" @default.
- NCIT_C155292 hasExactSynonym "18F Fluorinated PARP1-targeted Probe" @default.
- NCIT_C155292 hasExactSynonym "18F-1(2H)phthalazinone-based PARPi Imaging Agent" @default.
- NCIT_C155292 hasExactSynonym "18F-radiolabeled 1(2H)phthalazinone PARPi" @default.
- NCIT_C155292 hasExactSynonym "Fluorine F 18 PARP Inhibitor" @default.
- NCIT_C155292 hasExactSynonym "Fluorine F 18 PARPi" @default.
- NCIT_C155292 hasExactSynonym "Fluorine F 18 Poly(ADP-ribose) Polymerase Inhibitor" @default.
- NCIT_C155292 hasExactSynonym "[18F]PARP1-targeted Probe" @default.
- NCIT_C155292 hasExactSynonym "[18F]PARPi Imaging Agent" @default.
- NCIT_C155292 hasExactSynonym "[18F]PARPi" @default.
- NCIT_C155292 inSubset NCIT_C116977 @default.
- NCIT_C155292 inSubset NCIT_C116978 @default.
- NCIT_C155292 inSubset NCIT_C176424 @default.
- NCIT_C155292 type Class @default.
- NCIT_C155292 isDefinedBy ncit.owl @default.
- NCIT_C155292 label "Fluorine F 18 PARP Inhibitor" @default.
- NCIT_C155292 subClassOf NCIT_C1446 @default.
- NCIT_C155292 subClassOf NCIT_C155292 @default.
- NCIT_C155292 subClassOf NCIT_C1908 @default.
- NCIT_C155292 subClassOf NCIT_C1909 @default.
- NCIT_C155292 subClassOf NCIT_C2124 @default.