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- NCIT_C155293 IAO_0000115 "A preparation of autologous T-lymphocytes (ATL) that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, encoding human C-C chemokine receptor 4 (CCR4), linked via an internal ribosome entry site (IRES), to a chimeric antigen receptor (CAR) composed of a single chain single-chain variable fragment (scFv) directed against the CD30 antigen (CAR.CD30) and linked, via the spacer human IgG1 immunoglobulin heavy constant region (hinge-CH2CH3 region), to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration of the autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-lymphocytes, the expressed CCR4 on the T-cells allows for enhanced migration of the cells to chemokine-secreting tumor cells. The expressed CAR.CD30 moiety specifically recognizes and binds to CD30-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies. CCR4, a G-coupled-protein receptor for C-C chemokines normally expressed on regulatory T-cells (Tregs) but not on cytotoxic T-lymphocytes (CTLs), is involved in chemokine-mediated cellular migration. The co-expression of CCR4 on these CTLs may enhance their anti-tumor activity compared to T-lymphocytes expressing the same CAR-CD30 receptor but without CCR4 expression." @default.
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- NCIT_C155293 NCIT_NHC0 "C155293" @default.
- NCIT_C155293 NCIT_P106 "Cell" @default.
- NCIT_C155293 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C155293 NCIT_P107 "Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes" @default.
- NCIT_C155293 NCIT_P108 "Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes" @default.
- NCIT_C155293 NCIT_P208 "CL555926" @default.
- NCIT_C155293 NCIT_P322 "CTRP" @default.
- NCIT_C155293 NCIT_P329 "794781" @default.
- NCIT_C155293 NCIT_P330 "794781" @default.
- NCIT_C155293 NCIT_P399 "794781" @default.
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- NCIT_C155293 NCIT_R72 NCIT_C32725 @default.
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- NCIT_C155293 normalizedInformationContent "100" @default.
- NCIT_C155293 referenceCount "1" @default.
- NCIT_C155293 hasExactSynonym "ATLCAR.CD30-CD28zeta-CCR4 Cells" @default.
- NCIT_C155293 hasExactSynonym "ATLCAR.CD30.CCR4 Cells" @default.
- NCIT_C155293 hasExactSynonym "ATLs Co-expressing CD30-CARCD28zeta and CCR4" @default.
- NCIT_C155293 hasExactSynonym "Anti-CD30-CAR/CD28z-CCR4 Retroviral Vector-transduced Autologous T-Cells" @default.
- NCIT_C155293 hasExactSynonym "Autologous CCR4-CAR-CD19-CD28-zeta-transduced T-lymphocytes" @default.
- NCIT_C155293 hasExactSynonym "Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes" @default.
- NCIT_C155293 hasExactSynonym "CCR4-CAR-CD30-28zeta-specific Autologous T-cells" @default.
- NCIT_C155293 hasExactSynonym "SFG.CCR4-CAR.CD30 Autologous T-lymphocytes" @default.
- NCIT_C155293 inSubset NCIT_C116977 @default.
- NCIT_C155293 inSubset NCIT_C116978 @default.
- NCIT_C155293 inSubset NCIT_C128784 @default.
- NCIT_C155293 inSubset NCIT_C176424 @default.
- NCIT_C155293 type Class @default.
- NCIT_C155293 isDefinedBy ncit.owl @default.
- NCIT_C155293 label "Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes" @default.
- NCIT_C155293 subClassOf NCIT_C129820 @default.
- NCIT_C155293 subClassOf NCIT_C129821 @default.
- NCIT_C155293 subClassOf NCIT_C129826 @default.
- NCIT_C155293 subClassOf NCIT_C137999 @default.
- NCIT_C155293 subClassOf NCIT_C142078 @default.
- NCIT_C155293 subClassOf NCIT_C154231 @default.
- NCIT_C155293 subClassOf NCIT_C155293 @default.
- NCIT_C155293 subClassOf NCIT_C1908 @default.
- NCIT_C155293 subClassOf NCIT_C1909 @default.
- NCIT_C155293 subClassOf NCIT_C1962 @default.
- NCIT_C155293 subClassOf NCIT_C200766 @default.
- NCIT_C155293 subClassOf NCIT_C201513 @default.
- NCIT_C155293 subClassOf NCIT_C274 @default.
- NCIT_C155293 subClassOf NCIT_C28681 @default.
- NCIT_C155293 subClassOf NCIT_C307 @default.
- NCIT_C155293 subClassOf NCIT_C308 @default.