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- NCIT_C155294 IAO_0000115 "A preparation of autologous T-lymphocytes (ATL) that have been transduced with the retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, encoding a chimeric antigen receptor (CAR) composed of a single chain single-chain variable fragment (scFv) directed against the CD30 antigen (CAR.CD30) and linked, via the spacer human IgG1 immunoglobulin heavy constant region (hinge-CH2CH3 region), to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous CD30CAR-CD28-CD3zeta-expressing T-lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies." @default.
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- NCIT_C155294 NCIT_NHC0 "C155294" @default.
- NCIT_C155294 NCIT_P106 "Cell" @default.
- NCIT_C155294 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C155294 NCIT_P107 "Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes" @default.
- NCIT_C155294 NCIT_P108 "Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes" @default.
- NCIT_C155294 NCIT_P208 "CL555929" @default.
- NCIT_C155294 NCIT_P322 "CTRP" @default.
- NCIT_C155294 NCIT_P329 "794782" @default.
- NCIT_C155294 NCIT_P330 "794782" @default.
- NCIT_C155294 NCIT_P399 "794782" @default.
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- NCIT_C155294 NCIT_R72 NCIT_C12476 @default.
- NCIT_C155294 NCIT_R72 NCIT_C12508 @default.
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- NCIT_C155294 NCIT_R72 NCIT_C39567 @default.
- NCIT_C155294 NCIT_R72 NCIT_C39568 @default.
- NCIT_C155294 normalizedInformationContent "100" @default.
- NCIT_C155294 referenceCount "1" @default.
- NCIT_C155294 hasExactSynonym "ATL-expressing CD30-CAR-CD28zeta" @default.
- NCIT_C155294 hasExactSynonym "ATLCAR.CD30 Cells" @default.
- NCIT_C155294 hasExactSynonym "ATLCAR.CD30-CD28zeta Cells" @default.
- NCIT_C155294 hasExactSynonym "Anti-CD30-CAR/CD28z Retroviral Vector-transduced Autologous T-Cells" @default.
- NCIT_C155294 hasExactSynonym "Autologous CAR-CD19-CD28-zeta-transduced T-lymphocytes" @default.
- NCIT_C155294 hasExactSynonym "Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes" @default.
- NCIT_C155294 hasExactSynonym "CAR-CD30-28zeta-specific Autologous T-cells" @default.
- NCIT_C155294 hasExactSynonym "SFG.CAR.CD30 Autologous T-lymphocytes" @default.
- NCIT_C155294 inSubset NCIT_C116977 @default.
- NCIT_C155294 inSubset NCIT_C116978 @default.
- NCIT_C155294 inSubset NCIT_C128784 @default.
- NCIT_C155294 inSubset NCIT_C176424 @default.
- NCIT_C155294 type Class @default.
- NCIT_C155294 isDefinedBy ncit.owl @default.
- NCIT_C155294 label "Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes" @default.
- NCIT_C155294 subClassOf NCIT_C129820 @default.
- NCIT_C155294 subClassOf NCIT_C129821 @default.
- NCIT_C155294 subClassOf NCIT_C129826 @default.
- NCIT_C155294 subClassOf NCIT_C137999 @default.
- NCIT_C155294 subClassOf NCIT_C142078 @default.
- NCIT_C155294 subClassOf NCIT_C154231 @default.
- NCIT_C155294 subClassOf NCIT_C155294 @default.
- NCIT_C155294 subClassOf NCIT_C1908 @default.
- NCIT_C155294 subClassOf NCIT_C1909 @default.
- NCIT_C155294 subClassOf NCIT_C1962 @default.
- NCIT_C155294 subClassOf NCIT_C200766 @default.
- NCIT_C155294 subClassOf NCIT_C201513 @default.
- NCIT_C155294 subClassOf NCIT_C274 @default.
- NCIT_C155294 subClassOf NCIT_C28681 @default.
- NCIT_C155294 subClassOf NCIT_C307 @default.
- NCIT_C155294 subClassOf NCIT_C308 @default.