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- NCIT_C155654 IAO_0000115 "A humanized immunoglobulin G1 (IgG1)-variant monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, garivulimab specifically targets and binds to PD-L1, blocking its binding to and activation of its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This reverses T-cell inactivation caused by PD-L1/PD-1 signaling, increases T-cell expansion and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. In addition, BGB-A333 blocks the interaction between PD-L1 and its other receptor, the immunostimulatory molecule cluster of differentiation 80 (CD80; B7-1). This prevents PD-L1/CD80 signaling and inhibits the induction of PD-L1-induced apoptosis of activated CD8+ T-cells and increases T-cell proliferation. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 on activated T-cells suppresses the immune system and results in immune evasion. PD-1 negatively regulates T-cell activation." @default.
- NCIT_C155654 NCIT_A32 NCIT_C1909 @default.
- NCIT_C155654 NCIT_A7 NCIT_C96024 @default.
- NCIT_C155654 NCIT_NHC0 "C155654" @default.
- NCIT_C155654 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C155654 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C155654 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C155654 NCIT_P108 "Garivulimab" @default.
- NCIT_C155654 NCIT_P208 "CL556266" @default.
- NCIT_C155654 NCIT_P210 "2342597-81-1" @default.
- NCIT_C155654 NCIT_P319 "CSJ7UEQ4D9" @default.
- NCIT_C155654 NCIT_P322 "FDA" @default.
- NCIT_C155654 NCIT_P322 "GDC" @default.
- NCIT_C155654 NCIT_P329 "794412" @default.
- NCIT_C155654 NCIT_P330 "794412" @default.
- NCIT_C155654 NCIT_P375 "Anti-PD-L1 Monoclonal Antibody BGB-A333" @default.
- NCIT_C155654 NCIT_P399 "794412" @default.
- NCIT_C155654 NCIT_R124 NCIT_C17710 @default.
- NCIT_C155654 NCIT_R124 NCIT_C17828 @default.
- NCIT_C155654 NCIT_R124 NCIT_C18219 @default.
- NCIT_C155654 NCIT_R124 NCIT_C19986 @default.
- NCIT_C155654 NCIT_R124 NCIT_C40474 @default.
- NCIT_C155654 normalizedInformationContent "100" @default.
- NCIT_C155654 referenceCount "1" @default.
- NCIT_C155654 hasExactSynonym "Anti-PD-L1 Monoclonal Antibody BGB-A333" @default.
- NCIT_C155654 hasExactSynonym "BGB A333" @default.
- NCIT_C155654 hasExactSynonym "BGB-A333" @default.
- NCIT_C155654 hasExactSynonym "BGBA333" @default.
- NCIT_C155654 hasExactSynonym "GARIVULIMAB" @default.
- NCIT_C155654 hasExactSynonym "Garivulimab" @default.
- NCIT_C155654 inSubset NCIT_C128784 @default.
- NCIT_C155654 inSubset NCIT_C157711 @default.
- NCIT_C155654 inSubset NCIT_C157712 @default.
- NCIT_C155654 inSubset NCIT_C176424 @default.
- NCIT_C155654 inSubset NCIT_C177537 @default.
- NCIT_C155654 inSubset NCIT_C63923 @default.
- NCIT_C155654 type Class @default.
- NCIT_C155654 isDefinedBy ncit.owl @default.
- NCIT_C155654 label "Garivulimab" @default.
- NCIT_C155654 subClassOf NCIT_C128057 @default.
- NCIT_C155654 subClassOf NCIT_C129821 @default.
- NCIT_C155654 subClassOf NCIT_C129822 @default.
- NCIT_C155654 subClassOf NCIT_C141144 @default.
- NCIT_C155654 subClassOf NCIT_C143250 @default.
- NCIT_C155654 subClassOf NCIT_C155654 @default.
- NCIT_C155654 subClassOf NCIT_C156893 @default.
- NCIT_C155654 subClassOf NCIT_C163758 @default.
- NCIT_C155654 subClassOf NCIT_C1908 @default.
- NCIT_C155654 subClassOf NCIT_C1909 @default.
- NCIT_C155654 subClassOf NCIT_C191689 @default.
- NCIT_C155654 subClassOf NCIT_C20401 @default.
- NCIT_C155654 subClassOf NCIT_C274 @default.
- NCIT_C155654 subClassOf NCIT_C307 @default.
- NCIT_C155654 subClassOf NCIT_C308 @default.