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- NCIT_C155773 IAO_0000115 "The hydrochloride salt form of denfivontinib, an orally bioavailable inhibitor of both wild type and mutant forms of FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon administration, denfivontinib binds to and inhibits the activity of FLT3, including FLT3-ITD (internal tandem duplications), FLT3-D835Y as well as other mutants. This inhibits uncontrolled FLT3 signaling and results in the inhibition of proliferation in tumor cells overexpressing FLT3. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B lineage neoplasms and in acute myeloid leukemias, and plays a key role in tumor cell proliferation. In addition, denfivontinib also inhibits, to a lesser degree, the receptor tyrosine kinases AXL (UFO), Mer, Ret, vascular endothelial growth factor receptor 1 (VEGFR1), Fms, fibroblast growth factor receptors (FGFR) 1 and 3, and the serine/threonine kinases Aurora B and C." @default.
- NCIT_C155773 NCIT_A32 NCIT_C1909 @default.
- NCIT_C155773 NCIT_A7 NCIT_C26202 @default.
- NCIT_C155773 NCIT_NHC0 "C155773" @default.
- NCIT_C155773 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C155773 NCIT_P107 "Denfivontinib Hydrochloride" @default.
- NCIT_C155773 NCIT_P108 "Denfivontinib Hydrochloride" @default.
- NCIT_C155773 NCIT_P208 "CL556252" @default.
- NCIT_C155773 NCIT_P210 "1457983-33-3" @default.
- NCIT_C155773 NCIT_P319 "01ZQ25VJAL" @default.
- NCIT_C155773 NCIT_P322 "CTRP" @default.
- NCIT_C155773 NCIT_P322 "FDA" @default.
- NCIT_C155773 NCIT_P322 "GDC" @default.
- NCIT_C155773 NCIT_P329 "794986" @default.
- NCIT_C155773 NCIT_P330 "794986" @default.
- NCIT_C155773 NCIT_P375 "FLT3 Inhibitor SKI-G-801" @default.
- NCIT_C155773 NCIT_P399 "794986" @default.
- NCIT_C155773 normalizedInformationContent "100" @default.
- NCIT_C155773 referenceCount "1" @default.
- NCIT_C155773 hasExactSynonym "DENFIVONTINIB HYDROCHLORIDE" @default.
- NCIT_C155773 hasExactSynonym "Denfivontinib Hydrochloride" @default.
- NCIT_C155773 hasExactSynonym "FLT3 Inhibitor SKI-G-801" @default.
- NCIT_C155773 hasExactSynonym "FLT3 Kinase Inhibitor SKI-G-801" @default.
- NCIT_C155773 hasExactSynonym "FLT3 Tyrosine Kinase Inhibitor SKI-G-801" @default.
- NCIT_C155773 hasExactSynonym "G-749 HCl Salt" @default.
- NCIT_C155773 hasExactSynonym "G-749 Hydrochloride" @default.
- NCIT_C155773 hasExactSynonym "G-801" @default.
- NCIT_C155773 hasExactSynonym "SKI-G-801" @default.
- NCIT_C155773 inSubset NCIT_C116977 @default.
- NCIT_C155773 inSubset NCIT_C116978 @default.
- NCIT_C155773 inSubset NCIT_C128784 @default.
- NCIT_C155773 inSubset NCIT_C157711 @default.
- NCIT_C155773 inSubset NCIT_C157712 @default.
- NCIT_C155773 inSubset NCIT_C176424 @default.
- NCIT_C155773 inSubset NCIT_C177537 @default.
- NCIT_C155773 inSubset NCIT_C63923 @default.
- NCIT_C155773 type Class @default.
- NCIT_C155773 isDefinedBy ncit.owl @default.
- NCIT_C155773 label "Denfivontinib Hydrochloride" @default.
- NCIT_C155773 subClassOf NCIT_C124800 @default.
- NCIT_C155773 subClassOf NCIT_C1404 @default.
- NCIT_C155773 subClassOf NCIT_C155773 @default.
- NCIT_C155773 subClassOf NCIT_C163758 @default.
- NCIT_C155773 subClassOf NCIT_C163790 @default.
- NCIT_C155773 subClassOf NCIT_C1908 @default.
- NCIT_C155773 subClassOf NCIT_C1909 @default.
- NCIT_C155773 subClassOf NCIT_C1967 @default.
- NCIT_C155773 subClassOf NCIT_C274 @default.
- NCIT_C155773 subClassOf NCIT_C471 @default.